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EC number: 297-628-2
CAS number: 93685-80-4
data is being read across from the source study that tested
Hydrocarbons, C10-C12, isoalkanes,, <2% aromatics based on analogue read
SHELLSOL TC was administered by inhalation
to albino rats for 6 hours/day, 5 days/week for 13 weeks at nominal
vapor concentrations of 10400 mg/m3, 5200 mg/m3,
and 2600 mg/m3 to assess inhalation toxicity. No mortality
or treatment-related effects in any of the hematology and serum
chemistry values were observed. Liver and kidney weights were increased
in male rats at all exposure levels, male heart weights were increased
at the highest exposure level and liver and kidney weights were
increased in female rats at 10400 mg/m3. In addition, the male rats
exposed to SHELLSOL TC at all concentrations showed tubular degeneration
and hyaline inclusion-droplets in the epithelium. There was also
scattered degeneration of the proximal renal tubules which showed
cytoplasmic pallor and shrinkage. Occasionally the degenerate tubules
were surrounded by a lymphocyte infiltrate. Many tubules also showed
dilatation of the cortico-medullary junction, the dilated tubule being
filled with a flocculent eosinophilic material. The kidney effects
observed in male rats are indicative of alpha-2u-globulin nephropathy.
Alpha-2u-globulin nephropathy, also known as hyaline droplet
nephropathy, results from the formation of complexes with a naturally
occurring protein (alpha-2u-globulin) in the kidneys of male rats.
These complexes can accumulate in the proximal renal tubule and may
produce species-specific histopathological changes. These kidney
effects are specific to male rats and are not considered to be of
biological relevance to humans. Histopathological examination did not
reveal any abnormalities that were considered treatment related. As
there were no pathologic changes, changes in organ weights mentioned
above were judged to have been compensatory rather than toxic effects.
Based on these results, the No Observed Adverse Effect Concentration
(NOAEC) was greater than or equal to 10400 mg/m3.
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