2-benzylideneheptanal

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Justification for type of information:

Data is from peer-reviewed journal

Data source

Reference

Reference 1

Reference Type:

review article or handbook

Title:

Food flavoring and compounds of related structure I. Acute oral toxicity .Test material: 2-benzylideneheptanal

Author:

P.M. Jenner, E.C. Hagan, Jean M. Taylor, E.L. Cook, O.G. Fitzhugh

Year:

1964

Bibliographic source:

Food and Cosmetics Toxicology. Vol. 2, Pg. 327, 1964.

Reference 2

Reference Type:

secondary source

Title:

Initial Risk-Based Prioritization of High Production Volume (HPV) Chemicals Cinnamyl Derivatives Category.Test material: 2-benzylideneheptanal

Author:

U. S. Environmental Protection Agency (EPA) Office of Pollution Prevention and Toxics (OPPT) Risk Assessment Division (RAD)

Year:

2009

Bibliographic source:

U.S. Environmental Protection Agency Risk-Based Prioritization Document Page no 14, April 2009

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

Principles of method if other than guideline:

Acute oral toxicity study of benzylideneheptanal was performed in Rat

GLP compliance:

not specified

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

2-benzylideneheptanal

EC Number:

204-541-5

EC Name:

2-benzylideneheptanal

Cas Number:

122-40-7

Molecular formula:

C14H18O

IUPAC Name:

2-benzylideneheptanal

Test material form:

liquid

Details on test material:

- Name of test material (as cited in study report): amylcinnamaldehyde
- Molecular formula : C14H18O
- Molecular weight: 202.2952 g/mol
- Smiles notation: c1(\C=C(\CCCCC)C=O)ccccc1
- InChl: 1S/C14H18O/c1-2-3-5-10-14(12-15)11-13-8-6-4-7-9-13/h4,6-9,11-12H,2-3,5,10H2,1H3/b14-11-
- Substance type: organic
- Physical state: Liquid

Specific details on test material used for the study:

- Name of test material (as cited in study report):Amyl cinnamic aldehyde
- Molecular formula:C14H18O
- Molecular weight :202.295 g/mole
- Substance type:organic
- Physical state:Liquid
- Purity:No data available
- Impurities (identity and concentrations):No data available

Test animals

Species:

rat

Strain:

Osborne-Mendel

Sex:

male/female

Details on test animals or test system and environmental conditions:

Details on test animal
TEST ANIMALS
- Source: No data available

- Age at study initiation: No data available
- Weight at study initiation: No data available
- Fasting period before study: 18 hr
- Housing: No data available
- Diet (e.g. ad libitum): No data available
- Water (e.g. ad libitum): ad libitum
- Acclimation period: No data available

ENVIRONMENTAL CONDITIONS
- Temperature (°C): No data available
- Humidity (%):No data available
- Air changes (per hr): No data available
- Photoperiod (hrs dark / hrs light): No data available

IN-LIFE DATES: From: To: No data availabl

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

unchanged (no vehicle)

Details on oral exposure:

No data available

Doses:

3730mg/kg

No. of animals per sex per dose:

Total:10
male:5
female:5

Control animals:

not specified

Details on study design:

Details on study design
- Duration of observation period following administration: 14 days (or other?):1weeks
- Frequency of observations and weighing: Observations for mortality and overt signs of effect were made daily.
- Necropsy of survivors performed: No data available
- Other examinations performed: clinical signs, body weight, other: No data available

Statistics:

Litchfield & Wilcoxon (1949).

Results and discussion

Preliminary study:

No data available

Effect levels

Sex:

male/female

Dose descriptor:

LD50

Effect level:

3 730 mg/kg bw

Based on:

test mat.

95% CL:

3 190 - 4 370

Remarks on result:

other: 50% mortality was observed

Mortality:

50% mortality was observed on 4hr-5days

Clinical signs:

other: Somnolence (general depressed activity),Prophryrin -like deposit around nose and eyes

Gross pathology:

No data available

Other findings:

No data available

Applicant's summary and conclusion

Interpretation of results:

other: Not classified

Conclusions:

LD50 was considered to be 3730mg/kg body weight.When Osborne Mendel rats were treated with 2- benzylideneheptanal (122-40-7) orally.

Executive summary:

Acute oral toxicity study was done in both sex of Osborne Mendelrat using test material 2-benzylideneheptanal (122-40-7).10 animals were used. Fasting period before study was 18hr .water provided ad libitum .Test material given by oral gavage .Clinical signs observed after a few hours,Somnolence (general depressed activity),Prophryrin -like deposit around nose and eyes preceded death.50% mortality observed on 4hr-5days at dose concentration 3730.0mg/kg body weight.Hence LD50 was considered to be 3730mg/kg body weight.When Osborne Mendel rats were treated with 2- benzylideneheptanal (122-40-7) orally.