2-benzylideneheptanal

Skin irritation / corrosion

Administrative data

Endpoint:

skin irritation: in vivo

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Justification for type of information:

data is from peer reviewed journal

Data source

Reference

Reference Type:

publication

Title:

Fundamental Studies of Safe Compound Perfumes for Cosmetics Part 1 The Primary Irritation of Compound Materials to the Skin

Author:

Toshio Takenaka, Eiko Hasegawa, Umeko Takenaka, Fumio Saito M. D. and Tazuko Odaka M. D

Year:

1968

Bibliographic source:

Journal of J.C.C.A. Special Issue (1968) Pg 313–329

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

other: as mentioned below

Principles of method if other than guideline:

A primary skin test of alpha-Amyl cinnamaldehyde (CAS No: 122-40-7) was carried out by mean of closed patch to examine the degree of skin irritancy caused by the chemical on 108 human subjects.

GLP compliance:

not specified

Test material

Test material information

Constituent 1

Reference substance name:

2-benzylideneheptanal

EC Number:

204-541-5

EC Name:

2-benzylideneheptanal

Cas Number:

122-40-7

Molecular formula:

C14H18O

IUPAC Name:

2-benzylideneheptanal

Test material form:

liquid

Details on test material:

- Name of test material: (2E)-2-(phenylmethylidene)heptanal
- Molecular formula: C14H18O
- Molecular weight: 202.2952 g/mol
- Smiles notation: c1(\C=C(\CCCCC)C=O)ccccc1
- InChl: 1S/C14H18O/c1-2-3-5-10-14(12-15)11-13-8-6-4-7-9-13/h4,6-9,11-12H,2-3,5,10H2,1H3/b14-11-
- Substance type: Organic
- Physical state: Liquid

Specific details on test material used for the study:

- Name of test material: (2E)-2-(phenylmethylidene)heptanal
- Molecular formula: C14H18O
- Molecular weight: 202.2952 g/mol
- Smiles notation: c1(\C=C(\CCCCC)C=O)ccccc1
- InChl: 1S/C14H18O/c1-2-3-5-10-14(12-15)11-13-8-6-4-7-9-13/h4,6-9,11-12H,2-3,5,10H2,1H3/b14-11-
- Substance type: Organic
- Physical state: Liquid

Test animals

Species:

other: human

Strain:

other: not applicable

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Source: Tokyo, Osaka
- Age at study initiation:16-45 yrs of age
- Weight at study initiation: No data available
- Fasting period before study: No data available
- Housing: No data available
- Diet (e.g. ad libitum): No data available
- Water (e.g. ad libitum): No data available
- Acclimation period: No data available


ENVIRONMENTAL CONDITIONS
- Temperature (°C): No data available
- Humidity (%): No data available
- Air changes (per hr): No data available
- Photoperiod (hrs dark / hrs light): No data available

IN-LIFE DATES: From: To: September 1963- December 1967

Test system

Type of coverage:

occlusive

Preparation of test site:

not specified

Vehicle:

other: Cream base or 99% ethyl alcohol

Controls:

yes

Amount / concentration applied:

0.05-0.5 %

Duration of treatment / exposure:

24-48 hrs

Observation period:

30mins after patch removal

Number of animals:

108 humans

Details on study design:

- Area of exposure: back, forearm (flexor) and upperarm (inside flexion side)
- % coverage: No data available
- Type of wrap if used: No data available

REMOVAL OF TEST SUBSTANCE
- Washing (if done): No data available
- Time after start of exposure: No data available

Results and discussion

In vivo

Results

Irritation parameter:

overall irritation score

Basis:

mean

Time point:

24/48 h

Score:

1

Max. score:

108

Reversibility:

not specified

Remarks on result:

no indication of irritation

Remarks:

Only 1 subject showed positive erythema while negative results were observed in remaining subjects.

Irritant / corrosive response data:

Only 1 subject showed positive erythema while negative results were observed in remaining subjects.

Applicant's summary and conclusion

Interpretation of results:

other: not irritating

Conclusions:

The test material alpha-Amyl cinnamaldehyde (CAS No: 122-40-7) when applied as a patch did not show any reaction.

This suggests alpha-Amyl cinnamaldehyde (CAS No: 122-40-7) to be non irritant to the skin.

Executive summary:

A primary skin test of alpha-Amyl cinnamaldehyde (CAS No: 122-40-7) was carried out by mean of closed patch to examine the degree of skin irritancy caused by the chemical on 108 human subject.

 

alpha-Amyl cinnamaldehydewas applied to the back, forearm and upper arm of 108 male/female humans in Japan under occlusive condition at a concentration of 0.05-0.5% 24–48 h and the sites evaluated 30 min after the patches were removed. Cream base or ethyl alcohol was used as a vehicle.

 

Only 1 subject showed positive erythema while negative results were observed in remaining subjects (1/108). Thereforealpha-Amyl cinnamaldehyde (CAS No: 122-40-7)was considered to be non-irritant to the skin.