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EC number: -
CAS number: -
REACH_LD50 >2000 mg/kg | rat (male/female) |
OECD 423 | #key study#
Two groups, each of three female or three
male RccHan:WIST (SPF) rats, were treated with Sa 190 by oral gavage
administration at a dosage of 2000 mg/kg body weight. The test item was
formulated in corn oil at a concentration of 0.2 g/mL and administered
at a dosing volume of 10 mL/kg.
The animals were examined daily during the
acclimatization period and mortality, viability and clinical signs were
recorded. All animals were examined for clinical signs within the first
30 minutes and approximately 1, 2, 3 and 5 hours after treatment on day
1 and once daily during test days 2-15. Mortality/viability was recorded
within the first 30 minutes and approximately 1, 2, 3 and 5 hours after
administration on test day 1 (with the clinical signs) and twice daily
during days 2-15. Body weights were recorded on day 1 (prior to
administration) and on days 8 and 15. All animals were necropsied and
All animals survived until the end of the
No clinical signs were observed during the
course of the study in all three female animals. Slightly ruffled fur
was observed in two males following the treatment on day 1 only.
The body weight of the animals was within
the range commonly recorded for this strain and age.
No macroscopic findings were recorded at
The median lethal dose of SAT 080004 after
single oral administration to rats of both sexes, observed over a period
of 14 days, is:
LD50 (rat): greater than 2000 mg/kg body
Based upon the results of this study the
following classifications are proposed:
• According to the Commission Directive
2001/59/EC of 06 August 2001 (Official Journal of the European
Communities Nr. L 225/1, August 21, 2001), Sa 190 does not have to be
classified and labelled with respect to acute oral toxicity in the rat.
• According to the Regulation (EC) No
1272/2008 of the European Parliament and of the Council of 16 December
2008, Sa 190does not have to be classified and labelled with respect to
acute oral toxicity in the rat.
Acute Toxicity: oral
Based on the acute oral LD50
in rats (>2000 mg/kg) the substance does not need to be classified
for acute toxicity according to EU Classification, Labelling and
Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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