Registration Dossier

Administrative data

Endpoint:
hydrolysis
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Guideline study and GLP

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2014
Report Date:
2014

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
OECD Guideline 111 (Hydrolysis as a Function of pH)
GLP compliance:
yes (incl. certificate)

Test material

Reference
Name:
Unnamed
Type:
Constituent
Type:
Constituent

Results and discussion

Dissipation DT50 of parent compoundopen allclose all
pH:
4
Temp.:
20 °C
Remarks on result:
other: The rate constant/half-life period could not be determined due to the fast hydrolysis. The test item could not be detected
pH:
4
Temp.:
50 °C
Remarks on result:
other: The rate constant/half-life period could not be determined due to the fast hydrolysis. The test item could not be detected
pH:
4
Temp.:
70
Remarks on result:
other: The rate constant/half-life period could not be determined due to the fast hydrolysis. The test item could not be detected
pH:
7
Temp.:
20 °C
Hydrolysis rate constant:
0.006 h-1
DT50:
108 h
pH:
7
Temp.:
50
Hydrolysis rate constant:
0.018 h-1
DT50:
38 h
pH:
7
Temp.:
70
Hydrolysis rate constant:
0.143 h-1
DT50:
5 h
pH:
9
Temp.:
20 °C
Remarks on result:
other: The rate constant/half-life period could not be determined due to the fast hydrolysis. The test item could not be detected
pH:
9
Temp.:
50 °C
Remarks on result:
other: The rate constant/half-life period could not be determined due to the fast hydrolysis. The test item could not be detected
pH:
9
Temp.:
70 °C
Remarks on result:
other: The rate constant/half-life period could not be determined due to the fast hydrolysis. The test item could not be detected

Applicant's summary and conclusion

Validity criteria fulfilled:
yes
Conclusions:
The test substance is hydrolytically unstable at pH 4, 7 and 9