Registration Dossier

Administrative data

Description of key information

Key value for chemical safety assessment

Skin sensitisation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not sensitising)
Additional information:

The GPMT study was performed according to OECD guideline 406 and GLP (BASF SE, 1993). The results show that the 75% solution of ethylhexyl methoxycinnamate in olive oil only induces a minor skin reaction in the guinea pig. It can therefore be concluded that the substance ethylhexyl methoxycinnamate does not have sensitising properties to the skin according to the criteria outlined in the regulation 67/547/EEC and 1272/2008/EC (CLP/EU-GHS).


Migrated from Short description of key information:
Guinea Pig Maximisation Test (GPMT)(75% ethylhexyl methoxycinnamate in olive oil): not sensitising (OECD 406, GLP)

Respiratory sensitisation

Endpoint conclusion
Additional information:
Migrated from Short description of key information:
Not relevant, as inhalation of ethylhexyl methoxycinnamate is not expected.

Justification for classification or non-classification

Both the key and supporting sensitisation studies indicate that ethylhexyl methoxycinnamate does not provoke significant positive immunogenic reactions. The sensitisation rate in the key study does not exceed the critical value of 30%. Therefore, it can be concluded that the substance is not sensitising and therefore does not need to be classified as such according to the criteria outlined in 1272/2008/EC (CLP/EU-GHS).