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Description of key information

Oral:
- LD50 >5000 mg/kg bw
Dermal:
- LD50 >126.3 mg/kg bw
Inhalation:
- LC50 >511 mg/m3 air

Key value for chemical safety assessment

Additional information

In the key study (BASF SE, 1984, similar to current guideline studies, no GLP) for acute oral toxicity no effects in rats at a dose of 5000 mg/kg were observed. This was supported by an acute oral toxicity study (Pellimont, 1968, no guideline, no GLP) in mice, in which a high single oral dose of 8000 mg/kg/day ethylhexyl methoxycinnamate caused no deaths and only slight effects (temporarily cramps). The dose of 5000 mg/kg bw was chosen as most critical value.

In the key study (Kynnoch et al, 1977, precursor of OECD 402, no GLP) for acute dermal toxicity, no effects were observed at a concentration of 126.3 mg/kg bw ethylhexyl methoxycinnamate (based on 2.5% formulation). The LD50 is therefore higher than this tested value. No supporting studies were available.

In the key study (Martins and Paulutin, 1993, OECD 403, GLP) for acute inhalation toxicity no mortality at a concentration of 0.511 mg ethylhexyl methoxycinnamate/L air or 511 mg ethylhexyl methoxycinnamate/m3 air was observed. The LC50/LD50 is therefore higher than this tested value. No supporting studies were available.

Justification for classification or non-classification

No toxic effects (no mortality) were found in rats after oral, as well as dermal and inhalation exposure. The LD50 values were therefore established as greater than the highest doses tested. Based on these results, ethylhexyl methoxycinnamate can not be classified as acute toxic according to the criteria for classification outlined in Annex I of 1272/2008/EC and Annex VI of 67/548/EEC (no key parameters were established).