Registration Dossier

Administrative data

Description of key information

- Skin irritation
not irritating (Fed. Reg. 38, No. 187, section 1500.41, p. 27019, Sept. 27, 1973).
- Eye irritation
not irritating (J.H. Kay et col., in vivo Test de Draize, J.Soc.Cos.Chem. 13/281, 1962).

Key value for chemical safety assessment

Skin irritation / corrosion

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Eye irritation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Additional information

Skin irritation/corrosion potential of Ethylhexyl Methoxycinnamate was studied in white rabbits according to Fed. Reg. 38, No. 187, section 1500.41, p. 27019, Sept. 27, 1973 (BASF AG, 1985). Taking into consideration the stringent application conditions in the key study, i.e. 24 hours occlusive, only slight irritative potential of the test compound has been found. The findings do not fulfill the criteria as skin irritant according to regulation 67/547/EEC and 1272/2008/EC (CLP/EU-GHS).

The primary eye irritation potential of Ethylhexyl Methoxycinnamate was studied according to the in vivo Test de Draize (ref.: J.H. Kay et col., J.Soc.Cos.Chem. 13/281, 1962) in albino rabbits (Dufour, 1971). The results of this study do not fulfill the criteria as eye irritant according to regulation 67/547/EEC and 1272/2008/EC (CLP/EU-GHS).

Justification for classification or non-classification

Both the key study and supporting studies indicate that Ethylhexyl Methoxycinnamate does not induce significant or irreversible damage to the rabbit skin and eye. Therefore, it can be concluded that the substance is not irritating and therefore does not need to be classified as such according to the criteria outlined in 1272/2008/EC (CLP/EU-GHS).