Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 425-220-8 | CAS number: 5945-33-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicological Summary
- Administrative data
- Workers - Hazard via inhalation route
- Workers - Hazard via dermal route
- Workers - Hazard for the eyes
- Additional information - workers
- General Population - Hazard via inhalation route
- General Population - Hazard via dermal route
- General Population - Hazard via oral route
- General Population - Hazard for the eyes
- Additional information - General Population
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Acute/short term exposure
DNEL related information
Local effects
Acute/short term exposure
DNEL related information
Workers - Hazard via dermal route
Systemic effects
Acute/short term exposure
DNEL related information
Workers - Hazard for the eyes
Additional information - workers
DNEL for workers was not calculated for the dermal or inhalation routes since absorption of the substance thorough these routes is expected to be negligible according to the qualitative assessment of toxicokinetics. Following are the supportive argumentation:
Inhalation of Fyrolflex BDP is not expected. The substance is a viscous liquid at room temperature and has a low vapour pressure (1.2x10 -3 Pa). The Log P value is > 4 and this also does not favour absorption via passive diffusion directly across the respiratory tract epithelium.
Several skin tests were performed on Fyrolflex BDP provide a reasonable argument that Fyrolflex is not susceptible for absorption via the dermal route. The substance was determined experimentally as a non-sensitizer for skin and was not irritant in either skin or eye tests. Acute dermal toxicity data showed LD50>2000mg/kg bw. No systemic toxicity or other effects were observed. In addition, MW of 692g/mol the molecule might be too big for dermal uptake.
General Population - Hazard via inhalation route
Systemic effects
Acute/short term exposure
DNEL related information
Local effects
Acute/short term exposure
DNEL related information
General Population - Hazard via dermal route
Systemic effects
Acute/short term exposure
DNEL related information
General Population - Hazard via oral route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 1.67 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
DNEL related information
- Overall assessment factor (AF):
- 150
- Modified dose descriptor starting point:
- NOAEL
Acute/short term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 10 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
DNEL related information
- Overall assessment factor (AF):
- 25
- Modified dose descriptor starting point:
- NOAEL
General Population - Hazard for the eyes
Additional information - General Population
DNEL for general population was calculated for oral route of exposure based on experimental data (NOAEL of 1000mg/L in a 28-day repeat dose oral study). DNEL was not calculated neither for dermal nor for inhalation routes based on the following argumentation:
Inhalation of Fyrolflex BDP is not expected. The substance is a viscous liquid at room temperature and has a low vapour pressure (1.2x10 -3 Pa). The Log P value is > 4 and this also does not favour absorption via passive diffusion directly across the respiratory tract epithelium.Several skin tests were performed on Fyrolflex BDP provide a reasonable argument that Fyrolflex is not susceptible for absorption via the dermal route. The substance was determined experimentally as a non-sensitizer for skin and was not irritant in either skin or eye tests. Acute dermal toxicity data showed LD50>2000mg/kg bw. No systemic toxicity or other effects were observed. In addition, MW of 692g/mol the molecule might be too big for dermal uptake.
However, despite of the calculated DNELoral it is unlikely that the substance will be available through the oral route according to the following argumentation:
The molecular weight of the substance is 692g/mol, Log P=4.5 and a low solubility in water of 0.415mg/L, Fyrolflex BDP is not favorably for penetration across biological membranes and absorption into tissues (in accordance with the Guidance on Information Requirements and Chemical Safety Assessment, Chapter R.7C paragraph R.7.12 ).Any potential concern with respect to possible micellular solubilisation of the Fyrolflex BDP by reaction with bile salts in the small intestine may be insignificant since there were no systemic toxic effects observed in relevant in vivo studies at extremely high dose levels (up to 1000mg/L in a 28-day repeat dose oral study).Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.