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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: The study was performed according to OECD guideline study with GLP compliance.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1997

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
GLP compliance:
yes

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
solid: particulate/powder
Details on test material:
solid

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male/female

Administration / exposure

Vehicle:
CMC (carboxymethyl cellulose)
Doses:
0, 250, 500, 1000, 2000 mg/kg
No. of animals per sex per dose:
5
Control animals:
not specified

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
933 - 1 231 mg/kg bw
Remarks on result:
other: rat

Any other information on results incl. tables

MORTALITY:number of deaths at each dose:

Concentration mg BG Number of animal Number of deaths
w/v%* /kg bw per sex male female
2.5 250 5 0 0
5.0 500 5 0 0
10.0 1000 5 3 1
20.0 2000 5 3 4
BG: benzoguanamine (6-phenyl-1 3 5-triazine-2 4-diyldiamine)
* at 10 ml/kg bw

Applicant's summary and conclusion

Interpretation of results:
Toxicity Category IV
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
LD50 value = 933 mg/kg (male)
Executive summary:

Test speices, strain: rat, Sprague-Dawley

The major toxicity: edema in the forestomach

Oral LD50Males: 933 mg/kg bw(95% C.L. = 838 to 1808 mg/kg bw)

Females: 1231mg/kg bw (95% C.I. = 583 to 1494 mg/kg bw)