Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 273-728-1
CAS number: 69012-28-8
By-product of the manufacture of ferromanganese alloy containing primarily oxides of aluminum, manganese and silicon.
A guideline and GLP compliant prenatal development toxicity study
identified no effects of FeMn slag on the pregnant rat or on survival or
development of foetuses after dosing up to the limit dose of 1000
Contrary to the rat prenatal development data, in the rabbit prenatal
development study, adverse foetal effects were observed at all dose
levels (100, 300 or 800 mg/kg/day), with minor skeletal ossification
delays also apparent at 300 or 800 mg/kg/day. In view of the nature and
incidence of major fetal abnormalities detected in all treated groups, a
NOAEL for embryo-fetal development was not established. However, it
should be noted that the morphological changes in foetuses were
disparate and without a clear dose-response when the individual
incidences of anomalies were considered on a litter or foetal basis.
With regard to maternal toxicity, effects were largely comparable to
controls at all dose levels, however, clear vehicle tolerability issues
were apparent at all dose levels, demonstrated by 5 premature deaths (23
%) in the vehicle (Corn oil; 2 mL/kg dose volume) control group due to
gastro-intestinal disturbance, inappetence and embryo-foetal deaths,
abortions and/or litter resorptions. Though maternal clinical signs,
body weight gains and food intake were comparable to controls in all
groups, poor diet consumption reflecting GI disturbance in all groups,
including controls, reduces the reliability of these data. Whilst
post-implantation loss was marginally increased in females dosed at 800
mg/kg/day, the higher incidence of deaths in the controls which also had
marked embryo-foetal deaths has biased these data because the premature
decedent data are excluded from the mean values.
on the above, the registered substance is classified as Category 2
(H361) for developmental toxicity. This
reflects the uncertainty in the reliability of the rabbit prenatal
evidence, with adverse effects only observed in one species with
confounding vehicle effects, and no maternal or developmental effects of
prenatal exposure to FeMn slag in the other species. This is considered
to lower the concern for human relevance.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again