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EC number: 273-728-1
CAS number: 69012-28-8
By-product of the manufacture of ferromanganese alloy containing primarily oxides of aluminum, manganese and silicon.
This endpoint has been waived on the basis that the substance is not classified as a mutagen category 3.
In accordance with criteria for
classification as defined in Annex I, Regulation 1272/2008, the
substance does not require classification for carcinogenicity.
In accordance with Column 2 of REACH
Annex X, information requirement 8.9.1, a study may be proposed if:
- the substance has a widespread
dispersive use or there is evidence of frequent or long-term human
- the substance is classified as germ
cell mutagen category 2 or there is evidence from the repeated dose
study(ies) that the substance is able to induce hyperplasia and/or
As the substance was found to be
non-mutagenic from the conclusions of the genetic toxicity tests, and
there are no known reports of carcinogenicity in humans in the public
domain, testing for this endpoint is not proposed.
To substantiate the above, an extensive
review of literature (Assessment of Genotoxicity and Carcinogenicity of
inorganic-forms of Manganese, MHRP 2009) concluded through
weight-of-evidence that inorganic manganese, is not carcinogenic. This
is further supported by the UK HSE report Manganese and its inorganic
compounds (EH64 1999), which concludes that there is no evidence linking
Manganese to carcinogenicity in humans. The Scientific Committee on
Occupational Exposure Limits (SCOEL 2009) states “data on
carcinogenicity mutagenicity and genotoxicity are inconclusive and
inadequate to establish a definitive position on the carcinogenicity on
manganese and its compounds.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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