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EC number: 931-801-1
CAS number: -
OECD 404, rabbit, 4h semiocclusive: not irritating OECD 405, rabbit, not rinsed: not irritating
There is data from an in vivo skin irritation study in rabbits according
to OECD Guideline 404 available (Hempstock, 1998; Sponsor: Kao
Corporation). In this study 3 animals were exposed to 0.5 g of moistened
Fatty Amide O-N (oleamide) for 4 hours on shaved skin under
semiocclusive conditions. After the exposure period test substance
remains were gently removed and the skin reactions were assessed 1, 24,
48 and 72 hours after removal of the patch. No signs of skin irritation
were noted during the study, and observations were terminated after 72
hours. Under the conditions of the study the test material was not
irritating to the skin.
Data for eye irritation is available from an in vivo study in rabbits
conducted with Fatty Amide N-O (oleamide) in compliance with OECD
Guideline 405 (Hempstock, 1997; Sponsor: Kao Corporation). In this study
0.1 ml of test substance (corresponding to 62 mg) were initially
installed into the right eye of 1 animal, the left eye remained
untreated and served as control. Immediately after administration an
assessment of the initial pain reaction was made. After consideration of
the ocular responses in the first animal, the other 2 were treated in
identical manner. In order to minimise pain on application these animals
had received one drop of local anaesthetic before application. Readings
were performed at 1, 24, 48 and 72 hours and after 7 days to address
reversibility. No corneal or iridial effects were observed during the
7-day observation period of the study. Slight to moderate redness and
chemosis of the conjunctivae were observed, which were completely
reversible within the observation period and which were not sufficient
to induce a classification acording to the criteria of the DSD or the
CLP regulation. Therefore, the test material does not have to be
considered as irritating to the eyes.
According to the criteria of the DSD and the CLP regulation the
substance does not have to be classified as irritating to the skin or
irritating to eyes.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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