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EC number: 931-801-1
CAS number: -
Five male and five female RccHan:WIST (SPF) rats were treated with
erucamide at 2000 mg/kg by dermal application. The test item was applied
to a gauze patch moistened with water. The application period was 24
hours. The animals were examined daily during the acclimatization period
and mortality, viability and clinical signs were recorded. All animals
were examined for clinical signs within the first 30 minutes and at
approximately 1, 2, 3 and 5 hours after treatment on day 1 and once
daily during test days 2-15. Local signs were noted once daily from test
day 2 to 15. Mortality/viability was recorded within the first 30
minutes and at approximately 1, 2, 3 and 5 hours after administration on
test day 1 (with the clinical signs) and twice daily during days 2 - 15.
Body weights were recorded on day 1 (prior to administration) and on
days 8 and 15. All animals were necropsied and examined macroscopically.
No deaths occurred during the study. No clinical signs were evident
during the course of the study. The body weight of the animals was
within the range commonly recorded for this strain and age. Slight
desquamation was noted on day 7 - 8 of observation in a single male. All
other animals were without findings. No macroscopical findings were
evident. The median lethal dose of erucamide after single dermal
administration to rats of both sexes, observed over a period of 14 days,
is: LD50 (rat): greater than 2000 mg/kg body weight
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