Registration Dossier

Toxicological information

Exposure related observations in humans: other data

Administrative data

Endpoint:
exposure-related observations in humans: other data
Type of information:
other: Occupational exposure survey
Adequacy of study:
other information

Data source

Referenceopen allclose all

Reference Type:
other company data
Title:
Unnamed
Year:
2003
Reference Type:
other company data
Title:
Unnamed
Year:
1995
Reference Type:
other company data
Title:
Unnamed
Year:
1994

Materials and methods

Type of study / information:
Type of experience: other: Occupational exposure survey
Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Not applicable

Test material

Reference
Name:
Unnamed
Type:
Constituent

Results and discussion

Any other information on results incl. tables

The substance is produced and used in closed system. Personnel protection equipments (mask, gloves and safety glasses) are used during production, handling and use of the substance. Occupational exposure to 11-aminoundecanoic acid may mainly occurs by inhalation of particles.

No specific occupational exposure limits have been determined for 11-aminoundecanoic acid. To recognize the adverse effects of exposure to non toxic particle matter, a TLV-TWA of 10 mg/m3 for inhalable particle and a TLV-TWA of 3 mg/m3 for respirable particles have been establishedby ACGIH (2001).

An occupational exposure survey was conducted in the Atofina's production plant of Marseille-Saint Menet in 1994 and 1995.

In 1994, inhalable particulates were monitored one time at 2 working places and in the ambient air:

Activity 8-hour TWA (mg/m3)
Operator in charge of the packaging in big bags (Personal monitoring)    11.62
Driver of fork-lift trucks (Personal monitoring)    2.52
Ambient air close to the bag-filling machine (Static sampling)    8.8

Corrective measures were applied to reduce the exposure of the operator in charge of the packaging. New big bags were used for the packaging instead of recycled big bags, which were at the origin of the release of a large amount of inhalable particles.

According to this corrective measure, the 8-hour TWA at the packaging working areas was reduced to 0.90 mg/m3 (mean of 2 measurements), in a new measurement campain performed in 1995. Inhalable particles were assumed to be reduced in the same proportion for the driver of fork-lift trucks and in the ambient air close to the bag filling machine. This assumption was confirmed in subsequent occupational exposure surveys (Personal monitoring) performed in 2000, 2001, 2002 and 2003. All measurements were well below the TLV-TWA of 10 mg/m3 forinhalable particle and the TLV-TWA of 3 mg/m3 for respirable particles

Activity 8-hour TWA (mg/m3)
2000 2001 2002 2003
Operator in charge of the packaging in big bags 
Inhalable particle 2.13  - 3.4 0.53
Respirable particle <0.37  - <0.18 <0.08
Driver of fork-lift trucks   
Inhalable particle 1.0 0.04 0.91 1.83
Respirable particle <0.37 0.71 <0.18 <0.08
Tank loading
Inhalable particle <0.57 2.72  -  -
Respirable particle <0.37 0.35  -  -

Applicant's summary and conclusion