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EC number: 628-771-4
CAS number: 23357-46-2
The study was performed to assess the acute
toxicity following oral administration of 1-Aminotetralin in Wistar
rats. Single doses of 500 and 300 mg/kg body weight of test material
preparations in olive oil Ph.Eur./DAB were given to three administration
groups of three fasted female animals, each, (500 mg/kg in 3 females,
300 mg/kg in 6 females) by gavage in a sequential manner. Two animals of
the 500 mg/kg administration group were found dead within 4 hours after
application. No mortality occurred in the 300 mg/kg administration
groups. Clinical observation in one animal of the 500 mg/kg
administration group revealed poor general state, dyspnoea, lateral
position, clonic convulsions and salivation. Findings were observed from
hour 1 through to hour 3 after administration. No clinical signs and
findings were observed in another animal of the 500 mg/kg administration
group that died because lethality occurred immediately after
administration. In addition no clinical signs and findings were observed
in the surviving animal of the 500 mg/kg administration group. Clinical
observation in the first 300 mg/kg administration group revealed
impaired or poor general state, dyspnoea, lateral position, staggering,
ataxia, rolling or clonic convulsions and smeared fur. Findings were
observed from hour 0 through to study day 2 after administration.
Clinical observation in the second 300 mg/kg administration group
revealed impaired general state, dyspnoea and piloerection. Findings
were observed from hour 1 through to study day 1 after administration.
The body weight of the surviving animal of the 500 mg/kg administration
group increased during the first post exposure observation week but did
not adequately increase during the second week. The mean body weights of
the 300 mg/kg administration groups increased throughout the study
period. During necropsy one animal that died in the 500 mg/kg
administration group showed red erosion/ulcer in the glandular stomach.
No macroscopic pathologic abnormalities were noted in the other animal
that died (500 mg/kg: 1 female) and in the animals examined at the end
of the observation period (500 mg/kg: 1 female; 300 mg/kg: 6 females).
Under the conditions of this study the median lethal dose of
1-Aminotetralin after oral administration was found to be greater than
300 mg/kg and less than 500 mg/kg body weight in rats.
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