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EC number: 628-771-4
CAS number: 23357-46-2
The median lethal dose of 1-Aminotetralin (read across, CAS 2217-40-5) after oral administration was found to be greater than 300 mg/kg and less than 500 mg/kg body weight in rats (OECD 423).
The study was performed to assess the acute
toxicity following oral administration of 1-Aminotetralin (read across, CAS
2217-40-5) in Wistar rats. Single doses of 500 and 300 mg/kg body weight
of test material preparations in olive oil Ph.Eur./DAB were given to
three administration groups of three fasted female animals, each, (500
mg/kg in 3 females, 300 mg/kg in 6 females) by gavage in a sequential
manner. Two animals of the 500 mg/kg administration group were found
dead within 4 hours after application. No mortality occurred in the 300
mg/kg administration groups. During necropsy one animal that died in the
500 mg/kg administration group showed red erosion/ulcer in the glandular
stomach. No macroscopic pathologic abnormalities were noted in the other
animal that died (500 mg/kg: 1 female) and in the animals examined at
the end of the observation period (500 mg/kg: 1 female; 300 mg/kg: 6
females). Under the conditions of this study the median lethal dose of
1-Aminotetralin after oral administration was found to be greater than
300 mg/kg and less than 500 mg/kg body weight in rats. [BASF, 2006]
the available data for 1-Aminotetralin (read across, CAS 2217-40-5)
(R)-1-Aminotetralin is subject to C&L:
to Regulation 1272/2008/EC: acute oral tox. 4, H302 and
to Directive 67/548/EEC: acute oral tox.: R22
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