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EC number: 208-796-3
CAS number: 542-02-9
TABLE 1: Ocular reactions elicited by Acetoguanamine.
Rabbit Number and Sex
Region of Eye
Day after instillation
Opacity: degree of density (area most dense taken from reading)
0 No ulceration or opacity
1 Scattered or diffuse areas of opacity (other than slight dulling
of normal lustre), details of iris clearly visible
2 Easily discernible translucent areas, details of iris slightly
3 Nacrous areas, no details of iris visible, size of pupil barely
4 Opaque cornea, iris not discernible through the opacity
Area of cornea involved:
1 One quarter (or less) but not zero
2 Greater than one quarter, but less then half
3 Greater than half, but less than three quarters
4 Greater than three quarters, up to whole area
1 Markedly depened rugae, congestion, swelling, moderate
circumcorneal hyperaemia or injection, any of these or combination
of any thereof, iris still reacting
to light (sluggish reaction is positive)
2 No reaction to light, haemorrhage, gross destruction (any or all
Redness (refers to palpebral and bulbar conjunctivae cornea and
0 Blood vessels normal
1 Some blood vessels definitely hyperaemic (injected)
2 Diffuse, crimson colour, individual vessels not easily
3 Diffuse, beefy red
Chemosis (lids and/or nictitating membranes)
0 No swelling
1 Any swelling above normal (includes nictitating membranes)
2 Obvious swelling with partial eversion of lids
3 Swelling with lids about half-closed
4 Swelling with lids more than half-closed
In an eye irritation
study according to OECD 405 approx. 85 mg of Acetoguanamine, the weight
occupying a volume of 0.1 mL was placed into the lower lid of one eye of
each of the test animals (three adult New Zealand White rabbits).
Examination of the eyes was made after 1 hour, and 1, 2, 3, 4 and 7 days
after instillation. Irritation was scored and it was determined that Acetoguanamine
elicites only transient, corneal opacification and temporary
well-defined conjuctival reactions. Nevertheless this effects do not
lead to a classification of the test substance.
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