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EC number: 208-796-3
CAS number: 542-02-9
The aim of this study was to determine the 4 -hour LC50 value
of Acetoguanamine. Each five male and female rats were exposed to the
test atmosphere generated by dispersing the powder continously in air by
means of a "Wright" dust feed mechanism with a mean measured
concentration in the atmosphere of 2.031 mg/L for four hours (head-only
The animals were observed for motality and signs of intoxication during
exposure and daily thereafter for 14 days. The particle size was
determined with 6 separation stages corresponding to maximum mass median
aerodynamic diameters of 0.52, 0.93, 1.55, 3.5, 6.0 and 9.8 µm.
Exposure of Acetoguanamine at a single chamber concentration of 2.031
mg/L did not cause mortality. Minor signs of toxicity such as changes in
clinical conditions and small body weight loss in treated females were
considered not to be significant signs of toxicity.
Using standard assessment crtiteria Acetoguanamine can be classified as
non-toxic or slightly toxic. As the maximum practical concetration used
produced only slight signs of toxicity Acetoguanamine should probably be
classified as non-toxic.
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