Registration Dossier
Registration Dossier
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EC number: 234-217-9 | CAS number: 10599-90-3
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- disregarded due to major methodological deficiencies
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Secondary literature. Insufficient data for assessment.
Data source
Reference
- Reference Type:
- publication
- Title:
- Monochloramine hazard from a mixture of household cleaning solutions
- Author:
- Pinkus J.L.
- Year:
- 1 965
- Bibliographic source:
- The New england journal of medicine, vol. 272, No. 21, p. 1133.
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Preliminary animal inhalation hazard tests in a static chamber were performed.
- GLP compliance:
- no
- Test type:
- other:
- Limit test:
- no
Test material
- Reference substance name:
- vapors from equimolar quantities of sodium hypochlorite and ammonium hydroxide in water solution.
- IUPAC Name:
- vapors from equimolar quantities of sodium hypochlorite and ammonium hydroxide in water solution.
- Test material form:
- other: vapours
- Details on test material:
- - Name of test material (as cited in study report): Vapors from equimolar quantities of sodium hypochlorite and ammonium hydroxide in waer.
- Physical state: vapour
Constituent 1
Test animals
- Species:
- other: no data
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- No data
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Vehicle:
- other: water
- Details on inhalation exposure:
- Static chamber were used. No other data are available.
- Analytical verification of test atmosphere concentrations:
- not specified
- Duration of exposure:
- 15 min
- Concentrations:
- Unknown
- No. of animals per sex per dose:
- no data
- Control animals:
- not specified
- Details on study design:
- no data
- Statistics:
- no data
Results and discussion
Effect levels
- Sex:
- not specified
- Exp. duration:
- 15 min
- Remarks on result:
- other: No mortality was observed. Marked discomfort and severe dyspnea during fifteen minutes exposure were observed.
- Mortality:
- None
- Clinical signs:
- other: Marked discomfort and severe dyspnea during fifteen minutes exposure.
- Body weight:
- No data
- Gross pathology:
- No data
- Other findings:
- No data
Applicant's summary and conclusion
- Interpretation of results:
- other: Not applicable due to insufficient data
- Conclusions:
- Preliminary animal inhalation hazard tests in a static chamber indicated that vapours from equimolar quantities of sodium hypochlorite and ammonium hydroxide in water solution produced signs of marked discomfort and severe dyspnea during fifteen minutes exposure.
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