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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
disregarded due to major methodological deficiencies
Study period:
no data
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Documentation insufficient for assessment: only a short abstract is available in english. Original reference in Russian.

Data source

Reference
Reference Type:
publication
Title:
Peculiarities attending the appearance of chloramine edema of the lungs in rabbit at various age periods.
Author:
Arshavskaya E.I.
Year:
1975
Bibliographic source:
Biull Eskp Biol Med, 80 (9): 26-9.

Materials and methods

Test guideline
Qualifier:
no guideline followed
GLP compliance:
no
Test type:
other: no data
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Chloramide
EC Number:
234-217-9
EC Name:
Chloramide
Cas Number:
10599-90-3
Molecular formula:
ClH2N
IUPAC Name:
chloranamine
Details on test material:
- Name of test material (as cited in study report): Chloramine

Test animals

Species:
rabbit
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
oral: unspecified
Doses:
no data
No. of animals per sex per dose:
no data
Control animals:
not specified

Results and discussion

Effect levelsopen allclose all
Sex:
not specified
Dose descriptor:
other: Lethal dose
Effect level:
40 - 50 mg/kg bw
Remarks on result:
other: Rabbits under three weeks of age
Sex:
not specified
Dose descriptor:
other: Lethal dose
Effect level:
60 - 70 mg/kg bw
Remarks on result:
other: adult rabbits
Clinical signs:
other: No data
Gross pathology:
No data

Applicant's summary and conclusion

Interpretation of results:
other: Not applicable
Remarks:
Criteria used for interpretation of results: expert judgment
Conclusions:
Under the conditions of this study, rabbits under three weeks of age were found to be less tolerant to chloramine than adult rabbits.
Executive summary:

Rabbits under three weeks of age were found to be less tolerant to chloramine (CA) than adult rabbits. For them the lethal dose of CA was 40 - 50 mg/kg. They perished from intoxication with the symptoms of protracted collapse without any manifestations of edema. For older rabbits the lethal dose of CA was 60- 70 mg/kg. Death occurred with phenomena of acute sharp edema of the lungs. In young rabbits atypical edema of the lungs occurred only with the administration of very high doses of CA ( 200 - 250 mg/kg). Edematous fluid is present in small amount only; there is a prevalence of hemorrhage, this being possibly caused by a direct alterating action of the CA excreted through the lungs on the walls of the arterioles and capillaries of the vascular system of the lungs.