Registration Dossier
Registration Dossier
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EC number: 208-796-3 | CAS number: 542-02-9
Toxicological Summary
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- hazard unknown (no further information necessary)
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
- Most sensitive endpoint:
- acute toxicity
- Route of original study:
- By inhalation
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- hazard unknown (no further information necessary)
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
- Most sensitive endpoint:
- acute toxicity
DNEL related information
Workers - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- hazard unknown (no further information necessary)
Acute/short term exposure
- Hazard assessment conclusion:
- hazard unknown (no further information necessary)
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- hazard unknown (no further information necessary)
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
Workers - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- no hazard identified
Additional information - workers
According to „Guidance on information requirements and chemical safety assessment Part B: Hazard assessment” derivation of DNELs is not necessary if no adverse effects have been observed in studies at the highest recommended concentrations/doses tested. In all available acute toxicity tests Acetoguanamine is reported to cause no adverse effects at the highest recommended dose. Therefore no acute DNELs were derived.
No data from repeated dose toxicity studies, reproductive studies (including developmental toxicity) and carcinogenicity studies are available for Acetoguanamine. These studies are necessary to evaluate possible long term effects and derive long term DNELs on the basis of a reliable dose descriptor N(L)OAEL, benchmark dose etc. Because of this reason the registrant will derive long term DNELs for Acetoguanamine in case that adverse effects should appear in the proposed repeated dose studies.
General Population - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- hazard unknown (no further information necessary)
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- hazard unknown (no further information necessary)
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
General Population - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- hazard unknown (no further information necessary)
Acute/short term exposure
- Hazard assessment conclusion:
- hazard unknown (no further information necessary)
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- hazard unknown (no further information necessary)
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
General Population - Hazard via oral route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- insufficient hazard data available (further information necessary)
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
General Population - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- no hazard identified
Additional information - General Population
According to „Guidance on information requirements and chemical safety assessment Part B: Hazard assessment” derivation of DNELs is not necessary if no adverse effects have been observed in studies at the highest recommended concentrations/doses tested. In all available acute toxicity tests Acetoguanamine is reported to cause no adverse effects at the highest recommended dose. Therefore no acute DNELs could be derived.
No data from repeated dose toxicity studies, reproductive studies (including developmental toxicity) and carcinogenity studies are available for Acetoguanamine. These studies are necessary to evaluate possible long term effects and derive long term DNELs on the basis of a reliable dose descriptor N(L)OAEL, benchmark dose etc. Because of this reason the registrant will derive long term DNELs for Acetoguanamine in case that adverse effects should appear in the proposed repeated dose studies.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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