Registration Dossier
Registration Dossier
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EC number: 413-920-6 | CAS number: 88949-33-1
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
With high probability acutely not harmful to aquatic algae. No toxic effects occur at the range of solubility.
Key value for chemical safety assessment
Additional information
Two GLP-guideline studies according to OECD 201 have been conducted with the nano and the bulk form.
In the study with the nano form (RCC Ltd. 2008b) a dispersion (96 h saturation) with the loading rate of 100 mg/L has been tested due to the low solubility of the test substance. The undiluted filtrate without solvents or emulsifier was used. The EC50 (growth rate) after 72 h was determined to be above the solubility and the loading rate of 100 mg/L. No acute toxic effects occurred within the range of solubility. The shape and the size of the algal cells was not affected up to the highest concentration (undiluted filtrate).
A second study was conducted using the bulk form (RCC NOTOX 1993d): Exponentially growing cultures of Scenedesmus subspicatus were exposed to different dilutions of a supersaturated solution of the test item for 72 hours. Inhibition of cell growth was statistically significant only in 100% filtrate of the supersaturated solution of 100 mg/L, whereas significant stimulation of cell growth was recorded in dilutions of the filtrate.
In conclusion, exposure to test concentrations above the maximum solubility did not induce a biologically significant effect on algal growth. The NOEC and the 72-hour EC50 for both growth inhibition and growth rate reduction were greater than the maximum solubility of the substance in water.
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