Registration Dossier
Registration Dossier
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EC number: 413-920-6 | CAS number: 88949-33-1
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
With high probability acutely not harmful to aquatic invertebrates. No toxic effects occur within the range of solubility
Key value for chemical safety assessment
Additional information
Two static limits test were performed according to the OECD guideline 202 using Daphnia magna using the nano and the bulk form.
Due to the low water solubility of the test substance a dispersion (96 h saturation) with the loading rate of 100 mg/L was tested using the nano form (RCC Ltd. 2008a). The undiluted filtrate without solvents or emulsifier was used. No effects within the range of solubility could be observed. The NOEC/EC0 (48 h) was determined to be at least the loading rate of 100 mg/L. The EC50 and EC100 (48 h) were clearly above the loading rate of 100 mg/L.
A second limit test using the bulk form was conducted. Two different test solutions were used: A supersaturated solution of 100 mg/L dispersed with Cremophor RH 40 and additionally a filtrate of the supersaturated solution (RCC NOTOX 1993b). The supersaturated solution is a maximum dispersion due to the use of Cremophor RH 40. Since undissolved test material was observed that allowed exchange within the test system of soluble and dispersed particles, it is a worst case consideration for the bulk and the nano form since both forms have a similar behavior in environmental media according to the results of the OECD 318 guideline studies. The 48-hour EC50 was determined to be higher than the loading rate of 100 mg/L. The EC0 and EC100 are both higher than 100 mg/L. No mortality or visible abnormalities were observed during the test period of 48 hours.
Therefore, it can be stated that the nano and the bulk are with high probability acutely not harmful to daphnids.
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