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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: other routes

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Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
Not available, publication received 1942-06-25
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
documentation insufficient for assessment

Data source

Reference
Reference Type:
publication
Title:
The parenteral use of organic esters
Author:
Lipschitz W. L., Upham S. D., Hotchkiss C. N., Carlson G. H.
Year:
1942
Bibliographic source:
The Journal of Pharmacology and Experimental Therapeutics. 76(3): 189-193

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
- Principle of test: Examination of different organic esters for systemic toxicity, local irritation and action upon the neuro-muscular functions after intramuscular injection in the guinea pig's leg.
GLP compliance:
not specified
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
γ-valerolactone
EC Number:
203-569-5
EC Name:
γ-valerolactone
Cas Number:
108-29-2
Molecular formula:
C5H8O2
IUPAC Name:
5-methyloxolan-2-one
Specific details on test material used for the study:
No specified

Test animals

Species:
guinea pig
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
Not specified

Administration / exposure

Route of administration:
intramuscular
Vehicle:
unchanged (no vehicle)
Details on exposure:
2.5 mL/kg bw of the test item was injected with a short fine needle into the upper part of the leg of test animals
Doses:
2.5 mL/kg bw
No. of animals per sex per dose:
Not specified
Control animals:
not specified
Details on study design:
- Duration of observation period following administration: 7 days
- Frequency of observations and weighing: Continuously for serveral hours following the injection, therafter daily for one week
- Necropsy of survivors performed: No
- Clinical signs: Respiration, free-walking, locomotor reflexes, readiness and force with which the stretched leg was retracted, anatomical condition at the site of injection, changes in body weight
Statistics:
Not specified

Results and discussion

Effect levels
Key result
Sex:
not specified
Dose descriptor:
other: 75% of the animals died within 2 days
Effect level:
2 mL/kg bw
Based on:
test mat.
Remarks on result:
not determinable because of methodological limitations
Mortality:
75% of the animals died within 2 days
Clinical signs:
Deterioration of body functions, increased muscle toughness
Body weight:
Not specified
Gross pathology:
Not specified

Applicant's summary and conclusion