Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 203-569-5 | CAS number: 108-29-2
Exposure related observations in humans: other data
Administrative data
- Endpoint:
- exposure-related observations in humans: other data
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- Literature searched from 1962 through 1980
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Fragrance raw materials monographs: γ-VALEROLACTONE
- Author:
- Opdyke D.L.J.
- Year:
- 1 980
- Bibliographic source:
- Food Cosmet. T.
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- - Principle of test: Short summary of a study in humans.
- Short description of test conditions: 10% of the test item in diethyl phthalate were administered for 48 hours under occlusion to humans.
- Parameters analysed / observed: Skin irritation, parameters not further specified.
Original study by Kligman (1978) - GLP compliance:
- no
Test material
- Reference substance name:
- γ-valerolactone
- EC Number:
- 203-569-5
- EC Name:
- γ-valerolactone
- Cas Number:
- 108-29-2
- Molecular formula:
- C5H8O2
- IUPAC Name:
- 5-methyloxolan-2-one
Constituent 1
- Specific details on test material used for the study:
- No details given
Method
- Ethical approval:
- not specified
- Details on study design:
- 10% of the test item in diethyl phthalate were administered for 48 hours under occlusion to humans.
- Exposure assessment:
- not specified
- Details on exposure:
- Not specified
Results and discussion
- Results:
- The test item was found to be not irritating. Resuls were not further specified.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
