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EC number: 947-652-0
CAS number: 943986-70-7
an in vitro skin corrosion test using a human skin model (EpiDerm Skin
Model), the influence of the substance on the viability of human skin
was tested according to OECD 431 (2016) and GLP principles. The
substance was applied directly to 0.6 cm2 cultured skin (30.6 to 52.0
mg, in presence of 25 μL
Milli-Q water). Negative and positive controls were included. After 3
-minute and 1 -hour treatments the substance was removed and the
viability of the cells was tested by reduction of MTT. Viability of
unexposed skin was set at 100%. The relative mean tissue viability
obtained after 3-minute and 1-hour treatments with the substance
compared to the negative control tissues was 98% and 32%, respectively.
The positive control had a mean cell viability of 4.1% after 1 hour
exposure. The acceptability criteria of the study were met. Since the
mean relative tissue viability was not below 50% after the 3-minute
treatment and not below 15% after the 1-hour treatment, it can be
concluded that the substance is not corrosive in the in vitro skin
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