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Diss Factsheets
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EC number: 234-293-3 | CAS number: 11071-15-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Justification for type of information:
- Common functional groups
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- data waiving: supporting information
Reference
- Endpoint:
- basic toxicokinetics, other
- Type of information:
- other:
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Objective of study:
- toxicokinetics
- GLP compliance:
- not specified
- Radiolabelling:
- yes
- Details on absorption:
- Antimony compounds may be absorbed by inhalation and ingestion.
- Details on distribution in tissues:
- Absorbed trivalent antimony readily enters red blood cells and accumulates primarily in the spleen, liver and bone. No sex-or age-related differences in antimony concentrations were found.
In vitro experiments with human blood have shown that Antimony accumulated in the red blood cells of rats repeatedly exposed to antimony potassium tartrate via drinking water; concentrations of antimony measured in organs were much lower (spleen, liver >kidneys >brain, fat).
Lauwers et al (1990) estimated that the total body antimony pool in a patient who died following accidental antimony potassium tartrate ingestion was only five per cent of the ingested dose with high antimony concentrations in the liver, gall bladder and gastrointestinal mucosa. This is consistent with antimony undergoing enterohepatic circulation.
In two studies with rodents, the portion of the total body burden of antimony in the lungs was calculated with the help of isotope-labeled antimony. It was found that <1% was in the lungs 2 hours after inhalation exposure to an aerosol of trivalent or pentavalent antimony tartrate - Details on excretion:
- Antimony compounds are eliminated mainly in the urine, with small amounts appearing in faeces via bile after conjugation with glutathione.
- Metabolites identified:
- no
- Executive summary:
Antimony and compounds, considered suitable for read-across to Potassium Sodium Tartrate is absorbed by inhalation and ingestion and accumulates in red blood cells, the spleen, liver and bones. The main excretion pathway for antimony is reported to be via the kidneys.
- Reason / purpose for cross-reference:
- read-across: supporting information
Reference
- Endpoint:
- acute toxicity: dermal
- Type of information:
- other: Bibliographic source
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Justification for type of information:
- structural similarities.
- Reason / purpose for cross-reference:
- read-across: supporting information
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The method used for skin absorption toxicity was essentially that of SMYTH, H. F. Jr. CARPENTER,C. P.. 'Well. C.S.. POZZANI. U.C. and STRIEGEL. J. A. ( 1962).
Range-finding toxicity data: List VI. .-irner. Ind. lfyg. As.r. J, 23. 955 107. - GLP compliance:
- no
- Test type:
- fixed dose procedure
- Limit test:
- yes
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- female
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- The test material was applied in the amount of 0.5 g for solids and 0.5 ml for liquids or aqueous solutions. Aqueous solutions were made up by diluting pure materials or concentrated solutions to give percentages by weight. Solid materials were applied as powders. The material was applied to the designated patch areas and covered by a l-in.
square of surgical gauze two single layers thick. The gauze patches were held in place with strips of Elastoplast tape. The entire area was covered with a latex rubber film and secured with more Elastoplast tape. - Duration of exposure:
- 4 h
- No. of animals per sex per dose:
- 3
- Control animals:
- not specified
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- ca. 20 000 mg/kg bw
- Based on:
- test mat. (total fraction)
- Remarks on result:
- no indication of skin irritation up to the relevant limit dose level
- Conclusions:
- The results are indicated as Single Skin Penetration DL50, yielding a value of 20000 mg/Kg.
Data source
Reference
- Reference Type:
- publication
- Title:
- Acute toxicity and skin corrosion data for some organic and inorganic compounds and aqueous solutions
- Author:
- E.H.Vernot, J.D.MacEwen, C.C. Haun, and E.R.Kinkead
- Year:
- 1 977
- Bibliographic source:
- University of California, Irvine, Toxic Hazards Research Unit, Overlook Branch, Dayton, Ohio 45431 USA
Materials and methods
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Fumaric acid
- EC Number:
- 203-743-0
- EC Name:
- Fumaric acid
- Cas Number:
- 110-17-8
- Molecular formula:
- C4H4O4
- Test material form:
- not specified
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- female
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- Skin corrosion was tested using rabbits that had been clipped of all possible hair on backs and flanks 24 hr prior to exposure to allow for recovery of the skin from any irritation resulting from clipping. Six areas on the back, three on each side, were designated as patch areas to allow for the simultaneous testing of six materials per rabbit with six rabbits used for replicate testing of each series. Six areas on the back, three on each side, were designated as patch areas to allow for the simultaneous testing of six materials per rabbit with six rabbits used for replicate testing of each series. The material was applied to the designated patch areas and covered by a l-in.square of surgical gauze two single layers thick. The gauze patches were held in place with strips of Elastoplast tape. The entire area was covered with a latex rubber film and secured with more Elastoplast tape.
- Duration of exposure:
- 4 h
- Doses:
- Single skin penetration of 0.5g
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 20 000 mg/kg bw
Applicant's summary and conclusion
- Conclusions:
- Not classified
- Executive summary:
Antimony Potassium tartate, like other salts of tartaric acid has very low Kow, a very high water solubility (ca. 83 g/L)
and is is mostly ionised at phisiological pH. According to the description made in section 7.1. and to the indication in part 7a of the CSR
Guidance Document, passage through the stratum corneum of the skin of this substance is very unlikely. Taking into account that the
substance has not a high toxicity and is rapidly degraded or excreted, the performance of dermal toxicity tests is not warranted. Thereby it is not considered justified to perform a dermal toxicity test, although it is recognised that dermal exposure during manufacture and handling cannot be excluded.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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