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Diss Factsheets
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EC number: 234-293-3 | CAS number: 11071-15-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics, other
- Type of information:
- other:
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
Data source
Referenceopen allclose all
- Reference Type:
- review article or handbook
- Title:
- Toxicological Profile for Antimony and Compounds
- Author:
- Agency for Toxic Substances and Disease Registry
- Year:
- 2 017
- Bibliographic source:
- ATSDR
- Reference Type:
- publication
- Title:
- Scientific Basis for Swedish Occupational Standards XXI
- Author:
- Group for Occupational Standards
Ed. Johan Montelius - Year:
- 2 000
- Bibliographic source:
- National Institute for Working Life
- Reference Type:
- review article or handbook
- Title:
- ANTIMONY POTASSIUM TARTRATE
- Author:
- WN Harrison; SM Bradberry; JA Vale
- Year:
- 2 011
- Bibliographic source:
- UKPID MONOGRAPH
Materials and methods
- Objective of study:
- toxicokinetics
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Antimony
- EC Number:
- 231-146-5
- EC Name:
- Antimony
- Cas Number:
- 7440-36-0
- Molecular formula:
- Sb
Constituent 1
- Radiolabelling:
- yes
Results and discussion
Toxicokinetic / pharmacokinetic studies
- Details on absorption:
- Antimony compounds may be absorbed by inhalation and ingestion.
- Details on distribution in tissues:
- Absorbed trivalent antimony readily enters red blood cells and accumulates primarily in the spleen, liver and bone. No sex-or age-related differences in antimony concentrations were found.
In vitro experiments with human blood have shown that Antimony accumulated in the red blood cells of rats repeatedly exposed to antimony potassium tartrate via drinking water; concentrations of antimony measured in organs were much lower (spleen, liver >kidneys >brain, fat).
Lauwers et al (1990) estimated that the total body antimony pool in a patient who died following accidental antimony potassium tartrate ingestion was only five per cent of the ingested dose with high antimony concentrations in the liver, gall bladder and gastrointestinal mucosa. This is consistent with antimony undergoing enterohepatic circulation.
In two studies with rodents, the portion of the total body burden of antimony in the lungs was calculated with the help of isotope-labeled antimony. It was found that <1% was in the lungs 2 hours after inhalation exposure to an aerosol of trivalent or pentavalent antimony tartrate
- Details on excretion:
- Antimony compounds are eliminated mainly in the urine, with small amounts appearing in faeces via bile after conjugation with glutathione.
Metabolite characterisation studies
- Metabolites identified:
- no
Applicant's summary and conclusion
- Executive summary:
Antimony and compounds, considered suitable for read-across to Potassium Sodium Tartrate is absorbed by inhalation and ingestion and accumulates in red blood cells, the spleen, liver and bones. The main excretion pathway for antimony is reported to be via the kidneys.
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