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EC number: 234-293-3 | CAS number: 11071-15-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- other: bibliographic source
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
Data source
Referenceopen allclose all
- Reference Type:
- review article or handbook
- Title:
- Toxicity of Industrial Metals
- Author:
- Browning, E.
- Year:
- 1 969
- Bibliographic source:
- Appleton-Century-Crofts
- Reference Type:
- publication
- Title:
- On the nitrogen metabolism in experimental subacute arsenic and antimony poisoning
- Author:
- Pribyl, E.
- Year:
- 1 947
- Bibliographic source:
- U.S. Public Health Service Public Health Reports, Supplement No. 195
Materials and methods
- Principles of method if other than guideline:
- Rabbits were used as experimental animals and in one group a subacute poisoning by sodium arsenite and in the other by antimony potassium tartrate was produced. The urines were collected from metabolism cages every 24 hours and preserved with toluene. At regular intervals blood was taken from the marginal ear vein.
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- Dipotassium bis[μ-[tartrato(4-)-O1,O2:O3,O4]]diantimonate(2-) , stereoisomer
- EC Number:
- 234-293-3
- EC Name:
- Dipotassium bis[μ-[tartrato(4-)-O1,O2:O3,O4]]diantimonate(2-) , stereoisomer
- Cas Number:
- 11071-15-1
- Molecular formula:
- C8H4O12Sb2.2K
- IUPAC Name:
- (2R,3R)-2,3-dihydroxy-butanedioic acid, antimony potassium salt
Constituent 1
Test animals
- Species:
- other: rabbit
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- oral: feed
- Vehicle:
- other: milk and glucose
- Details on oral exposure:
- The rabbits were fed on 75 cc. of milk and 50 gm. of glucose per kilo of weight of rabbit per day in two meals, one at IO a.m. and one at 10 p.m. When the animals were unable to take food they were fed by stomach tube.
- Doses:
- The dose of antimony potassium tartrate given per os in solution was 10 and 15 mg., respectively, per kilo of body weight, being administered in serveral increasing doses.
- Control animals:
- other: Four rabbits were poisoned by sodium arsenite
Results and discussion
Effect levels
- Remarks on result:
- not measured/tested
- Mortality:
- No mortality
- Clinical signs:
- other: There was a rise in non-protein nitrogen and urea nitrogen in blood and urine. Te urea nitrogen quotient was almost the same in urines of Rabbits II and III. In Rabbit I there was a fall and in Rabbit IV a marked derecrease. The ammonia nitrogen quotient
- Gross pathology:
- Rabbit I : Hemorrhages in stomach and small intestine. Liver atrophied, of slight yellow color in the margin of the lobes. Kidneys were without pathological changes macroscopically. Microscopical Examination.-Liver: Parenchymal cells in the intermediary zone of the lobules contained fat; those at the periphery were in a state of beginning fatty degeneration. Kidneys : Slight congestion of tubules and glomeruli.
Rabbit Il.-The same pathological changes in gastrointestinal tract as in Rabbit I. Liver slightly congested and atrophied. Kidneys showed hemorrhages in the cortex. Microscopical Examination.-Liver: Fatty degeneration of cells in the intermediary zone of lobules marked. The peripheral cells without fat.
Kidneys: The lumina of tubules obliterated with necrosed cells.
Rabbit III.-Hemorrhages in stomach and small intestine. Liver showed marked atrophy and yellow color. Kidneys showed hemorrhages in the cortex.
Microscopical Examination.-Liver: Parenchymal cells in a state of necrosis. Nuclei not much stained; fatty degeneration advanced. Kidneys: Congestion of glomeruli.
Rabbit IV.-Congestion with hemorrhages in stomach and small intestine. Liver showed slight atrophy, yellow color. Kidneys showed the periphery of the cortex lighter in color. Microscopical Examination.-Liver: Parenchymal cells in the intermediary zone of the lobules contained fat; those of the periphery contained none. Kidneys: Glomeruli showed slight congestion.
Applicant's summary and conclusion
- Conclusions:
- Experimental subacute poisoning in four rabbits has shown that there is an increase of non-protein nitrogenin blood after administration of tartar emetic. The rise of non-protein nitrogen and urea nitrogen in blood is associated with an increase of these constituents in the urine.
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