Registration Dossier
Registration Dossier
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EC number: 227-217-5 | CAS number: 5718-26-3
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2017
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- column elution method
- Water solubility:
- 0.44 mg/L
- Conc. based on:
- test mat.
- Temp.:
- 20 °C
- pH:
- >= 6.2 - <= 7.4
- Conclusions:
- The water solubility of Macrolex Orange R was determined as 0.44 mg/L.
- Executive summary:
The water solubility of Macrolex Orange R was determined by the column elution method according to OECD Guideline 105, EC Guideline A.6.
The test item was eluted with water from a micro-column charged with silica gel, which was previously coated with an excess of the test item. At 20 °C fractions were collected at a flow rate of 12 mL/h (column 1) and at a flow rate of 24 mL/h (column 2). For each fraction 10 mL were collected. After dilution with acetonitrile the concentration of the test item in the solutions was determined by HPLC-UV-analysis. The water solubility was determined as 0.44 mg/L.
Reference
Fractions used for the determination of the water solubility
Column 1 (12 mL/h)
| Fraction no. | pH value | Concentration [mg/L] |
| 11 | 7.0 | 0.451879 |
| 12 | 7.0 | 0.443590 |
| 13 | 7.1 | 0.445686 |
| 14 | 6.8 | 0.443197 |
| 15 | 7.4 | 0.445771 |
Column 2 (24 mL/h)
| Fraction no. | pH value | Concentration [mg/L] |
| 3 | 7.0 | 0.424472 |
| 4 | 6.2 | 0.424415 |
| 5 | 6.9 | 0.426941 |
| 6 | 7.0 | 0.420873 |
| 7 | 7.0 | 0.428611 |
Description of key information
The water solubility of Macrolex Orange R was determined by the column elution method according to OECD Guideline 105, EC Guideline A.6.
The test item was eluted with water from a micro-column charged with silica gel, which was previously coated with an excess of the test item. At 20 °C fractions were collected at a flow rate of 12 mL/h (column 1) and at a flow rate of 24 mL/h (column 2). The water solubility was determined as 0.44 mg/L by HPLC-UV-analysis.
Key value for chemical safety assessment
- Water solubility:
- 0.44 mg/L
- at the temperature of:
- 20 °C
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
