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EC number: 284-366-9
CAS number: 84852-53-9
Guideline- and GLP-compliant rabbit eye and dermal irritation studies.
The test article (500 mg/site) was applied to one intact skin site on
each of six New Zealand White rabbits (3 males and 3 females). The
test article was administered once and remained in contact with the skin
for 4 hours. The skin was observed for erythema and
edema and scored according to the Draize Score at 30 to 60 minutes, 24,
48 and 72 hours after application of the test article. No
signs of erythema or edema were observed throughout the 72 hour
observation period in any of the animals on test. The
test article was not a dermal irritant.
The test article (100 mg/eye) was instilled into the right eye of each
of six New Zealand White rabbits (3 males and 3 females). Observations
were recorded at 1, 24, 48 and 72 hours after treatment and scored
according to the method of Draize. One positive ocular
score (due to redness of the conjunctiva in one animal) was recorded at
the 1 hour observation period. No other positive
scores were recorded at the 1, 24, 48 or 72 hour observation periods. All
scores were normal at the 72 hour observation period and the study was
terminated. The test article was not an eye irritant.
Results of rabbit (New Zealand White) skin and eye irritation studies
demonstrate the substance is not an irritant.
Non-classification: Results of rabbit (New Zealand White) skin and eye
irritation studies demonstrate the substance is not an irritant.
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