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EC number: 284-366-9
CAS number: 84852-53-9
Low and variable recovery of EBP. No metabolites identified.
McKinney et al. (2011) reported in vitro hepatic microsomal preparations
from polar bear, beluga whale, ringed seal, and rat did not metabolize
decabromodiphenyl ethane, BDE 209, 99, 100 or 154. As commented by Hardy
(2012), the low and variable recoveries of BDE 209 (81 +/- 9%) and
DBDP-Ethane (49 +/- 23%) in the controls, and the "depletion" observed
in the test groups, 14 to 25% for BDE 209 and 44 to 74% for DBDP-Ethane,
in the absence of identified metabolites suggest that factors other
metabolic conversion may be responsible. Hardy (2012) noted that both
substances are highly insoluble in aqueous media and many organic
solvents, and are prone to non-specific binding to surfaces and
particulates. Low solubility compounds are not properly assayed by many
in vitro systems due to their precipitation and/or adherence to walls of
the vessel, which eliminates interaction with microsomal enzymes (Kerns
and Di 2008). In GLP/guideline mutagenicity tests and bi-directional
cell permeability assays, poor solubility was observed with DBDPEthane
and BDE 209 (see Griffen 2008, Section 7). The ability to detect BDE 209
and DBDPEthane in the cell permiability assays was similar to McKinney
et al.'s pattern of recovery (higher for BDE 209 than DBDP-Ethane). (See
Hardy 2012 for details.) McKinney et al. commented that the low recovery
of DBDPEthane may be due to binding of reactive metabolites. However,
NOELs/NOAELs of >= 1000 mg/kg/d in repeated dose studies indicate that
significant amounts of reactive metabolites are not formed from
DBDPEthane. He et al. reported that lower brominated diphenyl ethanes
were not detected in rat tissues after 90-d oral administration of 100
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