Registration Dossier
Registration Dossier
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EC number: 406-750-9 | CAS number: 129757-67-1 TINUVIN 123
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- N.A.
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Test conducted according to GLP and Guideline 84/449/EWG, B.14 (Ames-Test)
Data source
Reference
- Reference Type:
- other: Body responsible for the test
- Title:
- Unnamed
- Year:
- 1 991
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.13/14 (Mutagenicity - Reverse Mutation Test Using Bacteria)
- Version / remarks:
- B.14 (Ames-test)
- Deviations:
- not specified
- GLP compliance:
- yes
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- Reaction mass of bis[2,2,6,6-tetramethyl-1- (octyloxy)piperidin-4-yl] decanedioate and 1,1'-bis[2,2,6,6-tetramethyl-1- (octyloxy)piperidin-4-yl] 10,10'-{octane-1,8-diylbis[oxy(2,2,6,6- tetramethylpiperidine-1,4-diyl)]} didecanedioate
- IUPAC Name:
- Reaction mass of bis[2,2,6,6-tetramethyl-1- (octyloxy)piperidin-4-yl] decanedioate and 1,1'-bis[2,2,6,6-tetramethyl-1- (octyloxy)piperidin-4-yl] 10,10'-{octane-1,8-diylbis[oxy(2,2,6,6- tetramethylpiperidine-1,4-diyl)]} didecanedioate
- Reference substance name:
- A mixture of: bis(2,2,6,6-tetramethyl-1-octyloxypiperidin-4-yl)-1,10-decanedioate; 1,8-bis[(2,2,6,6-tetramethyl-4-((2,2,6,6-tetramethyl-1-octyloxypiperidin-4-yl)-decan-1,10-dioyl)piperidin-1-yl)oxy]octane
- EC Number:
- 406-750-9
- EC Name:
- A mixture of: bis(2,2,6,6-tetramethyl-1-octyloxypiperidin-4-yl)-1,10-decanedioate; 1,8-bis[(2,2,6,6-tetramethyl-4-((2,2,6,6-tetramethyl-1-octyloxypiperidin-4-yl)-decan-1,10-dioyl)piperidin-1-yl)oxy]octane
- Cas Number:
- 129757-67-1
- Molecular formula:
- Constituent 1: C44H84N2O6 Constituent 2 : C80H150N4O12
- IUPAC Name:
- 2,2,6,6-tetramethyl-1-(octyloxy)piperidin-4-yl 2,2,6,6-tetramethyl-1-{[8-({2,2,6,6-tetramethyl-4-[(10-oxo-10-{[2,2,6,6-tetramethyl-1-(octyloxy)piperidin-4-yl]oxy}decanoyl)oxy]piperidin-1-yl}oxy)octyl]oxy}piperidin-4-yl decanedioate; 2,2,6,6-tetramethyl-1-(octyloxy)piperidin-4-yl 2,2,6,6-tetramethyl-4-{[8-({2,2,6,6-tetramethyl-1-[(10-oxo-10-{[2,2,6,6-tetramethyl-1-(octyloxy)piperidin-4-yl]oxy}decanoyl)oxy]piperidin-4-yl}oxy)octyl]oxy}piperidin-1-yl decanedioate; bis[2,2,6,6-tetramethyl-1-(octyloxy)piperidin-4-yl] decanedioate
- Reference substance name:
- Reaction mass of bis[2,2,6,6-tetramethyl-1- (octyloxy)piperidin-4-yl] decanedioate and 1,1'-bis[2,2,6,6-tetramethyl-1- (octyloxy)piperidin-4-yl] 10,10'-{octane-1,8-diylbis[oxy(2,2,6,6- tetramethylpiperidine-1,4-diyl)]} didecanedioate
- IUPAC Name:
- Reaction mass of bis[2,2,6,6-tetramethyl-1- (octyloxy)piperidin-4-yl] decanedioate and 1,1'-bis[2,2,6,6-tetramethyl-1- (octyloxy)piperidin-4-yl] 10,10'-{octane-1,8-diylbis[oxy(2,2,6,6- tetramethylpiperidine-1,4-diyl)]} didecanedioate
- Details on test material:
- see file attached under endpoint Appearance/physical state/color
Constituent 1
Constituent 2
Constituent 3
Method
Species / strain
- Species / strain / cell type:
- bacteria, other: sat TA 98, 100, 1535, 1537
- Metabolic activation:
- with and without
- Metabolic activation system:
- Aroclor-induced rat-liver S9
- Test concentrations with justification for top dose:
- Concentration range in the main test (with metabolic activation): 20... 5000 ug/plate
Concentration range in the main test (without metabolic activation): 20...5000 ug/plate - Vehicle / solvent:
- Solvent: Aceton
Results and discussion
Test resultsopen allclose all
- Species / strain:
- other: as specified above
- Metabolic activation:
- with
- Genotoxicity:
- not specified
- Cytotoxicity / choice of top concentrations:
- cytotoxicity
- Remarks:
- (> 5000 ug/plate)
- Vehicle controls validity:
- not specified
- Untreated negative controls validity:
- not specified
- Positive controls validity:
- not specified
- Species / strain:
- other: as specified above
- Metabolic activation:
- without
- Genotoxicity:
- not specified
- Cytotoxicity / choice of top concentrations:
- cytotoxicity
- Remarks:
- (> 5000 ug/plate)
- Vehicle controls validity:
- not specified
- Untreated negative controls validity:
- not specified
- Positive controls validity:
- not specified
- Remarks on result:
- other: other: preliminary test
- Remarks:
- Migrated from field 'Test system'.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information):
negative with metabolic activation
negative without metabolic activation
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