Registration Dossier
Registration Dossier
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EC number: 406-750-9 | CAS number: 129757-67-1 TINUVIN 123
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- N.A.
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP Compliance: yes according to guideline 84/449/EWG, B.4
Data source
Reference
- Reference Type:
- other: Body responsible for the test
- Title:
- Unnamed
- Year:
- 1 991
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion)
- Deviations:
- not specified
- GLP compliance:
- yes
Test material
- Reference substance name:
- Reaction mass of bis[2,2,6,6-tetramethyl-1- (octyloxy)piperidin-4-yl] decanedioate and 1,1'-bis[2,2,6,6-tetramethyl-1- (octyloxy)piperidin-4-yl] 10,10'-{octane-1,8-diylbis[oxy(2,2,6,6- tetramethylpiperidine-1,4-diyl)]} didecanedioate
- IUPAC Name:
- Reaction mass of bis[2,2,6,6-tetramethyl-1- (octyloxy)piperidin-4-yl] decanedioate and 1,1'-bis[2,2,6,6-tetramethyl-1- (octyloxy)piperidin-4-yl] 10,10'-{octane-1,8-diylbis[oxy(2,2,6,6- tetramethylpiperidine-1,4-diyl)]} didecanedioate
- Reference substance name:
- A mixture of: bis(2,2,6,6-tetramethyl-1-octyloxypiperidin-4-yl)-1,10-decanedioate; 1,8-bis[(2,2,6,6-tetramethyl-4-((2,2,6,6-tetramethyl-1-octyloxypiperidin-4-yl)-decan-1,10-dioyl)piperidin-1-yl)oxy]octane
- EC Number:
- 406-750-9
- EC Name:
- A mixture of: bis(2,2,6,6-tetramethyl-1-octyloxypiperidin-4-yl)-1,10-decanedioate; 1,8-bis[(2,2,6,6-tetramethyl-4-((2,2,6,6-tetramethyl-1-octyloxypiperidin-4-yl)-decan-1,10-dioyl)piperidin-1-yl)oxy]octane
- Cas Number:
- 129757-67-1
- Molecular formula:
- Constituent 1: C44H84N2O6 Constituent 2 : C80H150N4O12
- IUPAC Name:
- 2,2,6,6-tetramethyl-1-(octyloxy)piperidin-4-yl 2,2,6,6-tetramethyl-1-{[8-({2,2,6,6-tetramethyl-4-[(10-oxo-10-{[2,2,6,6-tetramethyl-1-(octyloxy)piperidin-4-yl]oxy}decanoyl)oxy]piperidin-1-yl}oxy)octyl]oxy}piperidin-4-yl decanedioate; 2,2,6,6-tetramethyl-1-(octyloxy)piperidin-4-yl 2,2,6,6-tetramethyl-4-{[8-({2,2,6,6-tetramethyl-1-[(10-oxo-10-{[2,2,6,6-tetramethyl-1-(octyloxy)piperidin-4-yl]oxy}decanoyl)oxy]piperidin-4-yl}oxy)octyl]oxy}piperidin-1-yl decanedioate; bis[2,2,6,6-tetramethyl-1-(octyloxy)piperidin-4-yl] decanedioate
- Reference substance name:
- Reaction mass of bis[2,2,6,6-tetramethyl-1- (octyloxy)piperidin-4-yl] decanedioate and 1,1'-bis[2,2,6,6-tetramethyl-1- (octyloxy)piperidin-4-yl] 10,10'-{octane-1,8-diylbis[oxy(2,2,6,6- tetramethylpiperidine-1,4-diyl)]} didecanedioate
- IUPAC Name:
- Reaction mass of bis[2,2,6,6-tetramethyl-1- (octyloxy)piperidin-4-yl] decanedioate and 1,1'-bis[2,2,6,6-tetramethyl-1- (octyloxy)piperidin-4-yl] 10,10'-{octane-1,8-diylbis[oxy(2,2,6,6- tetramethylpiperidine-1,4-diyl)]} didecanedioate
Constituent 1
Constituent 2
Constituent 3
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Type of coverage:
- semiocclusive
- Vehicle:
- other: none
- Controls:
- not specified
- Duration of treatment / exposure:
- 4 h
- Number of animals:
- 3
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Remarks:
- (mean score 1)
- Time point:
- other: overall at 24, 48, and 72 h
- Score:
- 0
- Reversibility:
- no data
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Remarks:
- (mean score 2)
- Time point:
- other: overall at 24, 48 and 72 h
- Score:
- 1
- Reversibility:
- no data
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Remarks:
- (mean score 3)
- Time point:
- other: overall at 24, 48 and 72 h
- Score:
- 0
- Reversibility:
- no data
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Remarks:
- (mean score 1)
- Time point:
- other: overall at 24, 48 and 72 h
- Score:
- 0
- Reversibility:
- no data
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Remarks:
- (mean score 2)
- Time point:
- other: overall at 24, 48 and 72 h
- Score:
- 0
- Reversibility:
- no data
- Irritation parameter:
- edema score
- Basis:
- animal #3
- Remarks:
- (mean score 3)
- Time point:
- other: overall at 24, 48 and 72 h
- Score:
- 0
- Reversibility:
- no data
- Irritant / corrosive response data:
- Reversibility of any observed effect: changes fully reversible within 7 days
Any other information on results incl. tables
Irritation parameter: erythema score
Max. Score: 1
Remarks: Max. duration: 72 h; Max. value at end of observation period: 0 (related to all animals)
Irritation parameter: edema score
Max. score: 0
Remarks: Max. duration: d; Max. value at end of observation period: 0 (related to all animals)
Applicant's summary and conclusion
- Interpretation of results:
- other: not classified
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