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EC number: 201-188-9
CAS number: 79-24-3
Table 1 Mean Methemoglobin (MetHb) Values for Rats Prior to the 93-Day Terminal Kill 13-Week Study
*Statistically significant deviation from control mean using Dunnett's test, p <0.05.
aNo statistical analysis was performed on this data since no control data was determined at this time period.
The subchronic toxicity of nitroethane was examined in rats. Groups of rats were exposed to 0, 100, 350, or 1000 ppm (0, 0.3, 1.0 or 3.0 mg/l) of NE for 6 hr/day, 5 days/wk for a total of 64-65 exposures with an interim sacrifice of rats after 20-21 exposures. Parameters monitored were clinical observations, body weights, organ weights, hematologic characteristics including methemoglobin (MetHb) determination, clinical chemistries, urinalysis, gross pathology and histopathology.
Exposure of rats to 1000 ppm NE resulted in decreased body weight gain, elevated MetHb levels with cyanosis, increased reticulocytes and Heinz bodies in peripheral blood and associated splenic congestion and extramedullary hematopoiesis. Other major target organ effects in these animals included degenerative and inflammatory changes in the olfactory nasal epithelium, hepatocellular vacuolization, decreased cytoplasmic granularity of renal cortical tubular epithelium and ductal epithelial cells of the salivary glands. Rats exposed to 350 ppm NE showed similar but less severe changes in MetHb, spleen, nasal turbinates and salivary glands. Minimal changes in MetHb, spleen and salivary glands were observed in rats exposed to 100 ppm.
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