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EC number: 201-188-9
CAS number: 79-24-3
In vitro study
In the in vitro study using H2O2, the distillate contained 77% of the original nitroethane and acetaldehyde in an amount equivalent to 16% of the nitroethane, leaving a loss of 7% in the recovery.
In the experiment without H2O2, 80% nitroethane and 18.5% of the nitroethane as acetaldehyde. No detectable acetaldehyde was observed in a sample of blood (no nitroethane added) treated in the same way.
In vivo study
Once 5% mercuric chloride followed by 1% sodium carbonate was used as a protein precipitant, the presence of increased nitrite after injections of nitroethane was then easily demonstrated. In the rabbit receiving 1.0 gram nitroethane intravenously, the values per 100 ml of blood for nitroethane and nitrite respectively were 58.5 and 0.60 mg after 30 minutes, 68.0 and 0.62 mg after 120 minutes and almost nil for both after 5 hours. The nitrite color of the 5 -hour sample, however, was definitely deeper than that shown for the blank. The proportion of nitrite found in comparison to the amount of nitroethane given and acetaldehyde previously found, was relatively low. This was probably due to the readiness with which oxyhemoglobin reacts with nitrite which is thus, for the most part, converted to nitrate.
In order to test this hypothesis, a rabbit was given 50 mg NaNO2 intravenously. The blood nitrite of this animal was 3.88 mg/100 ml after 5 minutes, 1.96 mg/100 ml after 45 minutes, 0.60 mg/100 after 120 minutes and 0.28 mg/100 ml after 240 minutes. The results indicate that the nitrite ion is rapidly removed from the blood until a certain level is reached, after which the decrease in concentration becomes more gradual.
Following intravenous administration of nitroethane, acetaldehyde and nitrite were found in relatively large amounts in rabbit blood.
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