reaction product of 3,5-di-tert-butylsalicylic acid and zirconium oxychloride, dehydrated, basic Zr : DTBS = 1.0 : 1.0 to 1.0 : 1.5

Acute Toxicity: dermal

Administrative data

Endpoint:

acute toxicity: dermal

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Data source

Reference

Reference Type:

other: Body responsible for the test

Title:

Unnamed

Year:

2001

Report date:

2001

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

other: 92/69/EWG, B.3; OECD 402 (1987)

GLP compliance:

yes

Test type:

other: OECD 402

Limit test:

yes

Test material

Test material information

Constituent 1

Test animals

Species:

other: rat, Sprague-Dawley HSD:CD

Administration / exposure

Type of coverage:

occlusive

Vehicle:

other: 1 % aqueous methylcellulose

Duration of exposure:

24 h

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LD50

Effect level:

> 2 000 mg/kg bw

Mortality:

Male: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 0
Female: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 0

Clinical signs:

other: Signs of toxicity related to dose levels: There were no deaths and no systemic response to treatment following a single application. No change in bodyweight was recorded for one female on Day 8 with a slight loss in bodyweight in the same animal on

Gross pathology:

Effects on organs:
No abnormalities were revealed at study termination.

Other findings:

Signs of toxicity (local):
There were no dermal reactions to treatment in any animal
throughout the study.

Applicant's summary and conclusion

Interpretation of results:

not classified

Remarks:

Migrated information Criteria used for interpretation of results: EU

Conclusions:

Not classified