Registration Dossier

Environmental fate & pathways

Hydrolysis

Currently viewing:

Administrative data

Endpoint:
hydrolysis
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: see 'Remark'
Remarks:
The data comes from a report of NATIONAL INDUSTRIAL CHEMICALS NOTIFICATION AND ASSESSMENT SCHEME (NICNAS), which is administered by the National Occupational Health and Safety Commission (NOHSC) of Australian Commission. Also the Data were determined using OECD test methods.

Data source

Reference
Reference Type:
review article or handbook
Title:
Phosphoric acid, (1-methylethylidene) di-4,1-phenylene tetraphenyl ester (Fyrolflex BDP)
Author:
National Occupational Health and Safety Commission (Australia)
Year:
2000
Bibliographic source:
European Union Risk Assessment Report

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
OECD Guideline 111 (Hydrolysis as a Function of pH)
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Type:
Constituent
Radiolabelling:
no

Study design

Analytical monitoring:
not specified
Details on sampling:
Incubating stoppered flasks containing (nominally) 0.25 mg/L in buffer solutions at pH 4,
7 and 9 for 5 days.
Duration of test
Duration:
5 d
Temp.:
25 °C
Initial conc. measured:
0.25 mg/L

Results and discussion

Dissipation DT50 of parent compoundopen allclose all
pH:
4
Temp.:
25 °C
DT50:
> 1 yr
Type:
other: The half life of BDP was greater than 1 year.
pH:
7
Temp.:
25 °C
DT50:
> 1 yr
Type:
other: The half life of BDP was greater than 1 year.
pH:
9
Temp.:
25 °C
DT50:
> 1 yr
Type:
other: The half life of BDP was greater than 1 year.

Applicant's summary and conclusion

Validity criteria fulfilled:
not specified
Conclusions:
The half life of hydrolytic degradation for BDP in 25 °C is greater than 1 year at environmental pH 4-9.
Executive summary:

Hydrolytic degradation of the compound was studied as a function of pH (Hogg A S, 1997) by incubating stoppered flasks containing (nominally) 0.25 mg/L in buffer solutions at pH 4, 7 and 9 for 5 days. The concentration of the compound in the solutions was determined using HPLC at various times over the 5 day (120 hour) test period. Very little degradation was observed in any of the buffers over the 5 day test period, with the maximum loss of 5% of initial concentration observed in the pH 9 buffer. These data indicate that the phosphate ester linkages within the molecules are stable to hydrolysis at 50°C. The small extent of observed degradation extrapolated to 25 °C indicates a half life of greater than 1 year at environmental pH 4-9.