Registration Dossier
Registration Dossier
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EC number: 464-320-6 | CAS number: 423772-95-6
Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
A study was performed to assess the chronic toxicity of the test item to Daphnia magna. The method followed was designed to be compatible with the OECD Guidelines for Testing of Chemicals (2012) No 211, "Daphnia magna Reproduction Test". Given that the toxicity cannot be attributed to a single component or a mixture of components, but to the test item as a whole, the results were based on nominal loading rates only.
The 21-Day EL50 (immobilization) value, based on nominal loading rates, for the parental Daphnia generation (P1) was estimated to be greater than 100 mg/L loading rate WAF.
The 21-Day EL50 (reproduction) value, based on nominal loading rates, was estimated to be greater than 100 mg/L loading rate WAF.
The 21-Day EL50 (length) value, based on nominal loading rates, was estimated to be greater than 100 mg/L loading rate WAF.
The No Observed Effect Loading Rate (NOEL) was considered to be 100 mg/L on the basis that at this test concentration there were no significant mortalities (immobilization) observed in the parental generation (P1) and that there were no biologically significant differences(P≥0.05) between the control and the 100 mg/L loading rate WAF test group in terms of numbers of live young produced and the length per adult by Day 21.
It was considered unnecessary and unrealistic to test at loading rates in excess of 100 mg/L.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 100 mg/L
Additional information
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