Methomyl

Acute Toxicity: other routes

Administrative data

Endpoint:

acute toxicity: other routes

Type of information:

experimental study

Adequacy of study:

supporting study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1972

Report date:

1972

Materials and methods

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

The test substance, in a 0.9% saline solution, was administered by intraperitoneal injection to rats in single doses. The LD50 value was calculated from mortality data.

GLP compliance:

no

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Methomyl

EC Number:

240-815-0

EC Name:

Methomyl

Cas Number:

16752-77-5

Molecular formula:

C5H10N2O2S

IUPAC Name:

(E)-[1-(methylsulfanyl)ethylidene]amino N-methylcarbamate

Test material form:

solid: crystalline

Specific details on test material used for the study:

- Substance name: Lannate methomyl, technical
- Substance ID: INX-1179-221
- Purity: Not reported

Test animals

Species:

rat

Strain:

other: ChR-CD

Sex:

male

Administration / exposure

Route of administration:

intraperitoneal

Vehicle:

other: 0.9% saline solution

Doses:

5, 10, 20 mg/kg

No. of animals per sex per dose:

5

Control animals:

no

Results and discussion

Effect levels

Key result

Sex:

male

Dose descriptor:

LD50

Effect level:

ca. 8 mg/kg bw

Based on:

test mat.

95% CL:

>= 5 - <= 15

Applicant's summary and conclusion

Conclusions:

Intraperitoneal LD50 (Rat): Approximately 8 mg/kg (95% CL: 5-15 mg/kg)

Executive summary:

The test substance, in a 0.9% saline solution, was administered by intraperitoneal injection to 3 groups of 5 young adult rats in single doses. Survivors were sacrificed 14 days later.

5, 3, and 1 animals were found dead at 20, 10, and 5 mg/kg, respectively. Clinical signs at lethal doses include, tremors, fasciculations, salivation, gasping, bulging eyes, pallor, prostration, with all animals dying within half an hour after dosing; chromodacryorrhea at 10 mg/kg and above. Clinical signs at non-lethal doses include, irregular respiration, pallor, fasciculations and prostration.

The test substance has high toxicity when administered by intraperitoneal injection to young adult male rats in single doses, its LD50 being approximately 8 mg/kg of body weight, with 95% confidence limits of 5 and 15 mg/kg.