Registration Dossier
Registration Dossier
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EC number: 225-533-8 | CAS number: 4904-61-4
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
The test substance does not pose a significant hazard to algae up to the limit of water solubility.
Key value for chemical safety assessment
Additional information
The test substance 1,5,9 -cyclododecatriene was tested in the Alga, Growth Inhibition Test according to the OECD Guideline for the Testing of Chemicals No. 201 (23 March 2006) using the single cell green algae Desmodesmus subspicatus as test organism. This study was selected as key study (Evonik, 2010; report no. 17585). The experiment was carried out as a static test, i.e. the test substance preparations were not exchanged for the whole exposure period of 72 hours. Based on non-GLP pre-test results the main test was performed with test substance concentrations of nominal 100 mg/L culture medium (limit test). During this study the test substance concentration of nominal 100 mg/L culture medium and the control (culture medium) was determined by the test site AQura GmbH by gas chormatography. The results of this study show that the test substance 1,5,9 -cyclododecatriene induced no inhibition of algal growth at the limit test concentration of 100 mg/L nominal (0.12 mg/L measured) with an EC50 (72h) for growth rate of > 0.12 mg/L (measured mean initial) and an NOEC for growth rate of >= 0.12 mg/L (measured mean initial), which constitutes the solubility limit of the test substance under test conditions.
The ErC50 (72 h), based on measured concentrations was determined as > 0.12 mg/L (measured mean initial), which constitutes the limit of solubility of the test substance under the conditions of this test. This indicates that the test substance does not pose a significant hazard to algae.
Only limited data are available on a second algae test with Pseudokirchneriella subcapitata as test species (Stephenson, 1982). However, the report is not available. Therefore, the reliability cannot be assessed due to the missing documentation (RL 4). The 96-h LC50 was determined to be approximately 140 mg/L based on growth rate.
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