Dioleamide

Additional toxicological data

Administrative data

Endpoint:

additional toxicological information

Type of information:

experimental study

Adequacy of study:

supporting study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

secondary literature

Data source

Reference

Reference Type:

publication

Title:

Unnamed

Year:

2015

Report date:

2014

Materials and methods

Principles of method if other than guideline:

To estimate the toxic hazards of compounds, Cramer rules were applied (Cramer et al. 1978). These rules allow molecules to be classified based on their molecular structure in a fast and simple way. Cramer rules classify molecules in three classes of toxicity, I–III. Class I expects low toxicity and class III suggests substantial toxicity. Class II would be an intermediate level. To achieve compound classification, software based on these rules was used. The obtained results revealed that both compounds belong to class III, therefore the toxicity of the compounds should be investigated in order to establish possible hazards to human health.

In order to estimate toxicity of molecules, Toxtree (Estimation of Toxic Hazard – A Decision Tree Approach) version 2.5.0, based in Cramer rules was used (Toxtree-2.6.0 2013).

GLP compliance:

no

Test material

Reference

Name:

Unnamed

Type:

Constituent

Test material form:

other: solidified melt waxy mass

Applicant's summary and conclusion

Conclusions:

The obtained results revealed that both dipalmitamide and dioleamide (oleyl oleamide) belong to class III, therefore the toxicity of the compounds should be investigated in order to establish possible hazards to human health.

Executive summary:

The obtained results revealed that both dipalmitamide and dioleamide (oleyl oleamide) belong to class III, therefore the toxicity of the compounds should be investigated in order to establish possible hazards to human health.