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EC number: 276-974-8 | CAS number: 72901-31-6
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Study period:
- 2017
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Qualifier:
- no guideline required
- Principles of method if other than guideline:
- - Software tool(s) used including version: EPSUITE WATERNT v. 1.01
- Model(s) used: WATERNT v. 1.01
- Model description: see field 'Attached justification'
- Justification of QSAR prediction: see field 'Attached justification - GLP compliance:
- no
- Type of method:
- other: QSAR
- Key result
- Water solubility:
- ca. 0 mg/L
- Conc. based on:
- test mat.
- Temp.:
- 25 °C
- pH:
- ca. 7
- Conclusions:
- Water solubility from Kow (WSKOW v1.42) is 5.9E-11 mg/L. Water solubility from WATERNT Program (v1.01) is 5.3196E-7 mg/L.
- Executive summary:
Water solubility from Kow (WSKOW v1.42) is 5.9E-11 mg/L. Water solubility from WATERNT Program (v1.01) is 5.3196E-7 mg/L.
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 13-Nov-2012 to 14-Mar-2013
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- GLP compliance:
- not specified
- Type of method:
- column elution method
- Key result
- Water solubility:
- < 0.01 mg/L
- Conc. based on:
- test mat.
- Temp.:
- 20 °C
- pH:
- > 6.6 - < 6.8
- Conclusions:
- Interpretation of results: insoluble (< 0.1 mg/L). The study of the source substance is consistent with the QSAR prediction of the target substance, bioth confirming a very low water solubility.
Referenceopen allclose all
Results
Flow rate (ml/h) |
Fraction No. |
Oleyl Palmitamide |
pH value |
25.0 |
1 (1-2) |
< 0.01 |
6.7 |
|
2 (3-4) |
< 0.01 |
6.7 |
|
3 (5-6) |
< 0.01 |
6.8 |
|
4 (7-8) |
< 0.01 |
6.8 |
|
5 (9-10) |
< 0.01 |
6.8 |
|
6 (11-12) |
< 0.01 |
6.8 |
|
7 (13-14) |
< 0.01 |
6.8 |
|
8 (15-16) |
< 0.01 |
6.8 |
|
|
|
|
12.5 |
1 (1-2) |
< 0.01 |
6.7 |
|
2 (3-4) |
< 0.01 |
6.7 |
|
3 (5-6) |
< 0.01 |
6.7 |
|
4 (7-8) |
< 0.01 |
6.7 |
|
5 (9-10) |
< 0.01 |
6.7 |
|
6 (11-12) |
< 0.01 |
6.7 |
|
7 (13-14) |
< 0.01 |
6.7 |
|
8 (15-16) |
< 0.01 |
6.7 |
Thus, the following value for water solubility of the test item Oleyl Palmitamide can be reported according to test procedure according to EU test method L142A/57-66 (EEC A.6).
Water solubility Oleyl Palmitamide < 0.01mg/l
pH value HPLC water: 6.6
The water solubility was determined at 20°C
Working range
The calibration curve fits over the whole working range from 0.01 to 2.06 mg/L with r2= 1. A quadratic fit was used.
Recovery
In the course of the recovery experiment, an average recovery rate of 117% was determined.
Description of key information
Key value for chemical safety assessment
- Water solubility:
- 0 µg/L
- at the temperature of:
- 25 °C
Additional information
The predicted value of 5E-11 mg/L indicates a very low to negligible water solubility of the compound. The experimentally determined water solubility of the read across source substance corroborates this assumption with a value below 0.1 mg/L and a comparably low predicted water solubility.
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