Registration Dossier
Registration Dossier
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EC number: 201-762-9 | CAS number: 87-66-1
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- The decarboxylation of some phenolic acids by the rat
- Author:
- Scheline, R.R.
- Year:
- 1 966
- Bibliographic source:
- Acta Pharmacol and Toxicol, 1966
Materials and methods
- Objective of study:
- metabolism
- Principles of method if other than guideline:
- Pyrogallol was adiminister to 4 adult albno rats by stomach tube or ip injection (100 mg/khg). After 24 h , urine samples were collected, extracted with ether and analyzed by TLC. Some of them were hydrolized acidic hydrolysis) before analysis..
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Pyrogallol
- EC Number:
- 201-762-9
- EC Name:
- Pyrogallol
- Cas Number:
- 87-66-1
- Molecular formula:
- C6H6O3
- IUPAC Name:
- benzene-1,2,3-triol
- Reference substance name:
- Unknown impurities
- IUPAC Name:
- Unknown impurities
- Test material form:
- not specified
- Details on test material:
- Not specified
Constituent 1
impurity 1
Test animals
- Species:
- rat
- Strain:
- other: albino
Administration / exposure
- Route of administration:
- other: oral:stomach tube or ip injection
- Vehicle:
- not specified
- Details on exposure:
- once
Doses / concentrations
- Dose / conc.:
- 100 mg/kg bw/day
- No. of animals per sex per dose / concentration:
- 4 total
Results and discussion
Main ADME results
- Type:
- metabolism
- Results:
- Pyrogallol was not detected in non hydrolyzed samples but was detected in those hydrolyzed, together with spots corresponding to resorcinol. This indicated that pyrogallol might be metabolized to resorcinol
Metabolite characterisation studies
- Metabolites identified:
- yes
- Details on metabolites:
- Pyrogallol was not detected in non hydrolyzed samples but was detected in those hydrolyzed, together with spots corresponding to resorcinol. This indicated that pyrogallol might be metabolized to resorcinol
Applicant's summary and conclusion
- Conclusions:
- Pyrogallol was not detected in non hydrolyzed samples but was detected in those hydrolyzed, together with spots corresponding to resorcinol. This indicated that pyrogallol might be metabolized to resorcinol
- Executive summary:
When pyrogallol was administered by gavage or i.p. injection to albino rats (sex not provided) at 100 mg/kg (0.79 mmol/kg), unchanged pyrogallol, 2-O-methylpyrogallol, and traces of resorcinol were detected in the urine. Pyrogallol was not detected in non hydrolyzed samples but was detected in those hydrolyzed, together with spots corresponding to resorcinol. This indicated that pyrogallol might be metabolized to resorcinol
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