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EC number: 246-874-9 | CAS number: 25340-17-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to reproduction
Administrative data
- Endpoint:
- screening for reproductive / developmental toxicity
- Remarks:
- based on generations indicated in Effect levels (migrated information)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1993
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Only short abstract available; GLP guideline study.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 993
- Report date:
- 1992
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 422 (Combined Repeated Dose Toxicity Study with the Reproduction / Developmental Toxicity Screening Test)
- Deviations:
- not specified
- Principles of method if other than guideline:
- Not applicable
- GLP compliance:
- yes
Test material
- Reference substance name:
- 1,4-diethylbenzene
- EC Number:
- 203-265-2
- EC Name:
- 1,4-diethylbenzene
- Cas Number:
- 105-05-5
- Molecular formula:
- C10H14
- IUPAC Name:
- 1,4-diethylbenzene
- Details on test material:
- IUCLID4 Test substance: other TS: 1,4-DEB
Identity: 1,4-Diethylbenzene (CAS No. 105-05-5)
Purity:97.2%
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- Male: 44 days including 14 days before mating; Female: up to 52 days including 14 days before mating to lactation day 3
- Frequency of treatment:
- Frequency of treatment: 7 days/week
Doses / concentrationsopen allclose all
- Dose / conc.:
- 30 mg/kg bw/day (nominal)
- Dose / conc.:
- 150 mg/kg bw/day (nominal)
- Dose / conc.:
- 750 mg/kg bw/day (nominal)
- No. of animals per sex per dose:
- 12 rats/sex/group
- Control animals:
- other: T27-03:Concurrent
- Details on study design:
- Control group and treatment: Concurrent Postexposure observation period: None
Terminal Kill: Male, day 45; Female, day 4 of lactation - Positive control:
- No data
Examinations
- Statistics:
- Not stated
Results and discussion
Results: P0 (first parental generation)
Details on results (P0)
There were no observed effects due to the test substance in the hematological findings for the treated males. Blood chemical examination revealed increases in levels of BUN and GPT in males given 150 and 750 mg/kg, and increases in levels of total protein, albumin, creatinine and total bilirubin and a decrease in the glucose level in the 750 mg/kg dose males. Absolute and relative kidney weights were elevated in the 150- and 750 mg/kg dose males. Moreover, absolute and relative weights of the liver were elevated in the 750 mg/kg-dose males and females. Necropsy revealed brown colored and enlarged livers in males given 750 mg/kg. Histopathological examination showed swelling of the liver cells in these animals.
NOELs for repeat dose toxicity are considered to be 30 mg/kg/day for males and 150 mg/kg/day for females.
NOAEL: 150 mg/kg/day
Toxic response/effects: Male and female copulation and fertility indices, pregnancy rates, and implantation sites were comparable among groups. The number of live and dead pups, the number of litters with live offspring, the mean litter size, and the male-to-female ratio were comparable among the groups on lactation day 0.
Duration of gestation was slightly, but statistically significantly, increased in the 750 mg/kg group and there was a statistically significant decrease in pup survival on day 4 in the 750 mg/kg group; however, the investigators did not consider these findings treatment-related.
Effect levels (P0)
open allclose all
- Dose descriptor:
- NOAEL
- Remarks:
- Parental
- Effect level:
- 30 mg/kg bw/day
- Based on:
- test mat.
- Sex:
- male
- Basis for effect level:
- other: Absolute Organ weight changes (liver and kidney) and clinical chemistry parameters.
- Dose descriptor:
- NOEL
- Remarks:
- parental
- Effect level:
- 150 mg/kg bw/day
- Based on:
- test mat.
- Sex:
- female
- Basis for effect level:
- other: Based on absolute and relative weights of the liver.
Results: F1 generation
Details on results (F1)
observed at necropsy in pups found dead prior to lactation day 4.
Effect levels (F1)
- Dose descriptor:
- NOAEL
- Remarks:
- Reprodutive/developmental
- Generation:
- F1
- Effect level:
- > 750 mg/kg bw/day
- Based on:
- test mat.
- Sex:
- male/female
- Basis for effect level:
- other: No treatment related reproductive toxicity observed
Overall reproductive toxicity
- Reproductive effects observed:
- no
Applicant's summary and conclusion
- Conclusions:
- 1,4-Diethylbenzene (105-05-5) does not appear to be a reproductive toxicant, although a slight effect was observed on duration of gestation.
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