Registration Dossier

Environmental fate & pathways

Bioaccumulation: aquatic / sediment

Currently viewing:

Administrative data

Link to relevant study record(s)

Description of key information

BCF was calculated to 14.83 L/kg ww (log BCF = 1.171). In addition, a BAF was estimated to 0.982 (log BAF = -008).

Key value for chemical safety assessment

BCF (aquatic species):
14.83 L/kg ww

Additional information

The log BCF of diisotridecyl adipate was estimated to be 1.171 (BCF = 14.83) using the program US EPA EPI Suite v4.00. In addition, a log BAF (upper trophic) of -0.008 (BAF = 0.982) was calculated using the method of Arnot-Gobas (MWC, 2010). The low BCF/BAF values indicate a low potential of diisotridecyl adipate for bioaccumulation in aquatic organisms.

The potential for accumulation of the read-across substance Bis(2-ethylhexyl)adipate (DEHA) in aquatic organisms was examined (Felder et al., 1986) in a bioconcentration test using bluegill sunfish (Lepomis macrochirus).The test used a flow through system that maintained the concentration of DEHA at about 250 µg/L using 14C-labeled DEHA. A steady state concentration of DEHA in the whole fish was attained by day 7. A whole fish bioconcentration factor (BCF) of 27 was reported at day 35. Daily BCFs of 3.2 to 46, 1.3 to 19, and 4.1 to 66 were reported for whole fish, fillet, and viscera samples, respectively. Following exposure to clean water, a depuration rate for DEHA of 0.26/day (t1/2 = 2.7 days) was determined.

DEHA is apparently rapidly and extensively excreted from the fish.

From the results of the in vivo-study on rats of Takahashi et al., 1981 on the read across-substance DEHA it can be concluded that the elimination of radioactivity from tissues and organs is very rapid and there is no specific organ affinity under the experimental conditions. There was no evidence of the accumulation of radioactivity in any organs or tissues.