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EC number: 203-906-6
CAS number: 111-77-3
The results as interpreted from the graphical information presented are
Concentrations in molar
No effects seen
*HepG-2 liver cancer cell line. All others Ishikawa cell lines
For DEGME, the EC50 was not seen for most end points up to the maximum
In an in vitro study using cells transfected with gene reporters, 24
chemicals found in fracking formulations were individually assessed for
possible endocrine antagonism effects. DEGME was found to have some
activity towards androgen, estrogen, progesterone and thyroid receptors
but not thyroid. However, the effects were weak and the dose response
curves shallow. IC50 values were not reached for the any of the tests
using the Ishikawa cell line up to the maximum tested concentration of
0.1mM and only just seen (IC50 ~0.1mM) for the anti-androgenic activity
of the reporter transfected into HepG-2 liver cancer cell line. Overall,
the reliability of this study as reported cannot be assessed for a
number of reasons, but particularly because no information is provided
on the number of replicates or concentrations tested and a complete lack
of statistical information.
The LOD for this substance for the method used seems quite high which
rather minimises the value of the information provided.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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