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EC number: 203-906-6
CAS number: 111-77-3
Functional observation battery: NOAEL>4000mg/kgbw/day
In a guideline (OECD 408) and GLP study, exposure to 2 -(2 -(2
-methoxyethoxy)ethoxy ethanol (TEGME) in the drinking water of rats at
doses up to 4 g/kg/day for 90 days did not result in clinical signs of
toxicity, alterations in the functional observational battery, or gross
or microscopic lesions in the nervous system. Minor decreases in motor
activity were observed in the 4 g/kg/day treatment group at the Day 60
(males only) and Day 90 (males and females) evaluation periods. These
decreases in motor activity were not considered to be
neurotoxicologically significant based on the small magnitude of the
changes, the parallel changes observed in body weights at these
evaluation periods, and the lack of corroborative behavioral effects
from the FOB evaluations or histological changes in central or
peripheral nervous system tissues. Based on these findings 4 g/kg/day is
a subchronic NOAEL for TEGME neurotoxicity.
The substance does not meet the criteria for classification due to
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