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EC number: 203-137-6 | CAS number: 103-71-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Skin irritation: in 2 valid studies phenyl isocyanate was
irritant/corrosive to the skin and in another study phenyl isocyanate
was not irritating to the skin.
Eye irritation: in one valid study phenyl isocyanate was highly
irritating to the eye.
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Qualifier:
- according to guideline
- Guideline:
- other: Code of Federal Regulations, Title 16, Section 1500.41
- Principles of method if other than guideline:
- 500 µl of phenyl isocyanate was applied on a 2.5 x 2.5 cm² area at the shaved (one side) and scarified (other side) trunk of 6 rabbits and fixed for 24 h. Reading was carried out 24, 48 and 72 h after start of application.
- GLP compliance:
- not specified
- Species:
- rabbit
- Strain:
- New Zealand White
- Type of coverage:
- semiocclusive
- Preparation of test site:
- other: shaved and scarified
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Duration of treatment / exposure:
- 24 hours
- Observation period:
- 8 days
- Number of animals:
- 6 animals
- Irritation parameter:
- primary dermal irritation index (PDII)
- Basis:
- mean
- Time point:
- other: 24, 72 h
- Score:
- >= 2
- Max. score:
- 8
- Reversibility:
- not fully reversible within: 8 days
- Remarks on result:
- other: no erythema score available after 24 and 72 h due to white discoloration of the skin
- Irritant / corrosive response data:
- Erythema score = 4 (after 8 days), edema score = 4 (24, 72 hours and 8 days).
- Other effects:
- White discoloration of the skin within 24 hours. Dryness, folding and red-brownish discoloration of the skin after 72 hours. Dry eschar formation after 8 days and beginning of ablation. No hair growth under eschar.
- Interpretation of results:
- Category 1 (corrosive) based on GHS criteria
- Conclusions:
- Phenyl isocyanate was regarded as strong irritant/corrosive to the skin. According to CLP classification criteria (Regulation (EC) No 1272/2008) a classification as Skin Corr. 1 is justified.
- Executive summary:
500 µl of the phenyl isocyanate was applied on a 2.5 x 2.5 cm² area at the shaved (one side) and scarificed (other side) trunk of 6 rabbits and fixed for 24 h. Reading was carried out 24 and 72 h after start of application.
Within 24 hours a white discoloration of the skin occurs, followed by dryness, folding of the skin after 72 hours. A dry eschar formation after 8 days and beginning of ablation was observed. No hair growth under the eschar.
The primary irritation index was> 2.0. Phenyl isocyanate was regarded as strong irritant/corrosive to the skin.
Reference
Phenyl isocyanate is strong irritant/corrosive to the skin.
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (corrosive)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Qualifier:
- according to guideline
- Guideline:
- other: Code of Federal Regulations, Title 16, Section 1500.42
- Principles of method if other than guideline:
- 100 µl phenyl isocyanate was applied into the conjunctival sac of the right eye of 6 rabbits. Reading was carried out 24, 48 and 72 h after start of application of the test substance.
- GLP compliance:
- not specified
- Species:
- rabbit
- Strain:
- New Zealand White
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Duration of treatment / exposure:
- 8 days (eye was not washed after application of the test substance)
- Observation period (in vivo):
- 8 days
- Number of animals or in vitro replicates:
- 6 animals
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 24, 48, 72 h
- Score:
- 49.8
- Max. score:
- 110
- Reversibility:
- not fully reversible within: 8 days
- Irritant / corrosive response data:
- Eight days after application of the test substance, no repair of the eye damages was observed, with a trend for deterioration. Phenyl isocyanate is therefore highly irritant to the eyes.
- Other effects:
- No repair of the effects within 8 days, with a trend for further deterioration
- Interpretation of results:
- Category 1 (irreversible effects on the eye) based on GHS criteria
- Conclusions:
- Eight days after application of the test substance, no repair of the eye damages was observed, with a trend for deterioration. Phenyl isocyanate is therefore classified as highly irritant. According to CLP classification criteria (Regulation (EC) No 1272/2008) a classification as Eye Damage 1 is justified.
- Executive summary:
100 µl phenylisocyanate was applied into the conjunctival sac of the right eye of 6 rabbits. Reading was carried out 24, 48 and 72 h after start of application of the test substance. A primary irritation score of 49.8 (of 110) was found. Eight days after application of the test substance, no repair of the eye damages was observed, with a trend for deterioration. Phenyl isocyanate is therefore classified as highly irritant.
Reference
Eight days after application of the test substance, no repair of the eye damages was observed, with a trend for deterioration.
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Additional information
In a guideline study according Code of Federal Regulations, Title 16, Section 1500.41, phenyl isocyanate was found strong irritant/corrosive. In 2 other study phenyl isocyanate was found irritating to skin or not irritating to skin.
In a guideline study according Code of Federal Regulations, Title 16, Section 1500.41, phenyl isocyanate was strong irritant to eyes. These findings were supported by 2 other study where phenyl isocyanate was corrosive (5 minute exposure); corrosive and extremely irritant (24 h exposure)
In addition, several acute inhalation toxicity studies reported respiration irritating effects.
Justification for classification or non-classification
Skin irritation: in 2 valid studies phenyl isocyanate was irritant/corrosive to the skin and in another study phenyl isocyanate was not irritating to the skin. According to CLP classification criteria (Regulation (EC) No 1272/2008) a classification as Skin Corr. 1C is justified on a weight-of-evidence consideration.
Eye irritation: In one valid study phenyl isocyanate was highly irritating to the eye. Eight days after the application of the test substance, no repair of the eye damages was observed with a trend for deterioration. According to CLP classification criteria (Regulation (EC) No 1272/2008) a classification as Eye Damage 1 is justified.
In addition, several acute inhalation toxicity studies reported respiration irritating effects. According to CLP classification criteria (Regulation (EC) No 1272/2008) a classification as STOT SE 3 ( H335: May cause respiratory irritation) is justified.
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